After the death of his father, Zhang Juzheng did not follow the rule to mourn his father for 27 months, but continued to work, known as Zhang’s DuoQing event. Because the event had a huge influence on the imperial court and Zhang Juzheng himself, the present paper analyzed the differences in written expressions of Zhang Juzheng before and after DuoQing event from a psychological semantic perspective. This paper used a classic Chinese dictionary, CC-LIWC, to analyze Zhang’s work (Memorials & letters), and obtained the word frequency of LIWC keywords, then compared their differences. We selected psychological semantically related CC-LIWC keywords for further analysis, including Functional-Personal pronouns, Affective processes, Social process, Cognitive process, Drives process, Personal concerns. The results indicated that only five dimensions of the Third person singular words, the Third person plural words, the Sadness words, the Female words and the Difference words were significantly different among the above keywords. This paper found that Zhang Juzheng was an efficient manager who loved power and work, the development of DuoQing event was beyond Zhang Juzheng’s expectation, and the incomprehension and impeachment from his close people made him sad. This paper provides a new method for analyzing one’s psychological changes before and after one major event, also provides some reference for modern leaders in terms of psychology and dealing with people.