Cognitive Deficits and Clinical Symptoms with Hippocampal Subfields in First-Episode and Never-Treated Patients with Schizophrenia | |
Xiu, Mei Hong6; Lang, XiaoE5; Chen, Da Chun6; Cao, Bo4; Kosten, Thomas R.3; Cho, Raymond Y.3; Shi, Hui2; Wei, Chang Wei2; Wu, An Shi2; Zhang, Xiang Yang1,7 | |
刊名 | CEREBRAL CORTEX |
2021 | |
卷号 | 31期号:1页码:89-96 |
关键词 | cognition first-episode never treated hippocampal subfields neuroimaging schizophrenia |
ISSN号 | 1047-3211 |
DOI | 10.1093/cercor/bhaa208 |
产权排序 | 6 |
文献子类 | 实证研究 |
英文摘要 | Memory dysfunction and associated hippocampal disturbances play crucial roles in cognitive impairment of schizophrenia. To examine the relationships between cognitive function and the hippocampal subfields (HSs) in first-episode never-treated (FENT) schizophrenia patients, the HSs were segmented in 39 FENT patients and 30 healthy controls using a state-of the-art automated algorithm. We found no significant differences in any HSs between the patients and controls. However, multivariate regression analysis showed that the left cornu ammonis 1 (CA1), left hippocampal tail, left presubiculum, and right molecular layer contributed 40% to the variance of the PANSS negative symptom score. After adjusting for sex, age, education, and intracranial volume, the partial correlation analysis showed that the volumes of left CA1, CA3, CA4, molecular layer, granule cell layer and both left and right subiculum were negatively correlated with the MATRICS consensus cognitive battery (MCCB) Hopkins Verbal Learning Test (HVLT). Multiple regression analysis showed that the left CA1 and CA3 hippocampal abnormalities contributed 66% to the variance of the HVLT. Our results suggest no detectable HS deficits were found in FENT schizophrenia patients. However, the HSs may be involved in the symptoms and cognitive deficits of schizophrenia patients in the early phase of their illness. |
资助项目 | Key Research Project in Shanxi Province[201803D31098] ; Wu Jieping Medical Foundation[320.6750.18336] ; National Key Research and Development Program of China[2017YFC1310405] ; National Natural Science Foundation of China[81771139] ; National Natural Science Foundation of China[81000509] ; National Natural Science Foundation of China[81371477] |
WOS关键词 | LONGITUDINAL COURSE ; TEST-PERFORMANCE ; BLOOD-VOLUME ; LIFE-SPAN ; SEGMENTATION ; MEMORY ; IMPAIRMENT ; VIVO ; DYSFUNCTION ; BATTERY |
WOS研究方向 | Neurosciences & Neurology |
出版者 | OXFORD UNIV PRESS INC |
WOS记录号 | WOS:000608401000007 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/38435] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Lang, XiaoE |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Capital Med Univ, Beijing Chao Yang Hosp, Beijing 100020, Peoples R China 3.Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX 77030 USA 4.Univ Alberta, Fac Med & Dent, Dept Psychiat, Edmonton, AB T6G 2B7, Canada 5.Shanxi Med Univ, Dept Psychiat, Hosp 1, Clin Med Coll 1, Taiyuan 03000, Peoples R China 6.Peking Univ, Beijing HuiLongGuan Hosp, HuiLongGuan Clin Med Sch, Beijing 100096, Peoples R China 7.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China |
推荐引用方式 GB/T 7714 | Xiu, Mei Hong,Lang, XiaoE,Chen, Da Chun,et al. Cognitive Deficits and Clinical Symptoms with Hippocampal Subfields in First-Episode and Never-Treated Patients with Schizophrenia[J]. CEREBRAL CORTEX,2021,31(1):89-96. |
APA | Xiu, Mei Hong.,Lang, XiaoE.,Chen, Da Chun.,Cao, Bo.,Kosten, Thomas R..,...&Zhang, Xiang Yang.(2021).Cognitive Deficits and Clinical Symptoms with Hippocampal Subfields in First-Episode and Never-Treated Patients with Schizophrenia.CEREBRAL CORTEX,31(1),89-96. |
MLA | Xiu, Mei Hong,et al."Cognitive Deficits and Clinical Symptoms with Hippocampal Subfields in First-Episode and Never-Treated Patients with Schizophrenia".CEREBRAL CORTEX 31.1(2021):89-96. |
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