Structural abnormalities of cingulate cortex in patients with first-episode drug-naive schizophrenia comorbid with depressive symptoms | |
Wei, Gao-Xia2,3,4; Ge, Likun2,4; Chen, Li-Zhen2,4; Cao, Bo1; Zhang, Xiangyang4 | |
刊名 | HUMAN BRAIN MAPPING |
2020-12-09 | |
卷号 | 42期号:6页码:1617-1625 |
关键词 | comorbidity gray matter psychiatry subcortical structures |
ISSN号 | 1065-9471 |
DOI | 10.1002/hbm.25315 |
产权排序 | 1 |
文献子类 | 实证研究 |
英文摘要 | Depressive symptoms are common in patients with first-episode psychosis. However, the neural mechanisms underlying the comorbid depression in schizophrenia are still unknown. The main purpose of this study was to characterize the structural abnormalities of first-episodes drug-naive (FEDN) schizophrenia comorbid with depression by utilizing both volume-based and surface-based morphometric measurements. Forty-two patients with FEDN schizophrenia and 29 healthy controls were recruited. The 24-item Hamilton Depression Rating Scale (HAMD-24) was administrated to divide all patients into depressive patients (DP) and non-depressive patients (NDP). Compared with NDP, DP had a significantly larger volume and surface area in the left isthmus cingulate cortex and also had a greater volume in the left posterior cingulate cortex. Correlation analysis showed that HAMD total score was positively correlated with the surface area of the left isthmus cingulate and gray matter volume of the left isthmus cingulate cortex. In addition, gray matter volume of the left isthmus cingulate was also correlated with the PANSS general psychopathology or total score. The findings suggest that prominent structural abnormalities of gray matter are mainly concentrated on the cingulate cortex in FEDN schizophrenia patients comorbid with depression, which may contribute to depressive symptoms and psychopathological symptoms. |
资助项目 | Scientific Foundation of Institute of Psychology ; Chinese Academy of Sciences[Y9CX402008] ; Open Research Fund of the CAS Key Laboratory of Behavioral Science, Institute of Psychology ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2011ZK07] ; National Natural Science Foundation of China[31671163] |
WOS关键词 | POSTERIOR CINGULATE ; MATTER ABNORMALITIES ; METAANALYSIS ; EPISODE ; VOLUME ; RISK ; PEOPLE ; MEMORY ; SCALE ; OLDER |
WOS研究方向 | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
语种 | 英语 |
出版者 | WILEY |
WOS记录号 | WOS:000596701500001 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/38206] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Zhang, Xiangyang |
作者单位 | 1.Univ Alberta, Fac Med & Dent, Dept Psychiat, Edmonton, AB, Canada 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China 4.Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China |
推荐引用方式 GB/T 7714 | Wei, Gao-Xia,Ge, Likun,Chen, Li-Zhen,et al. Structural abnormalities of cingulate cortex in patients with first-episode drug-naive schizophrenia comorbid with depressive symptoms[J]. HUMAN BRAIN MAPPING,2020,42(6):1617-1625. |
APA | Wei, Gao-Xia,Ge, Likun,Chen, Li-Zhen,Cao, Bo,&Zhang, Xiangyang.(2020).Structural abnormalities of cingulate cortex in patients with first-episode drug-naive schizophrenia comorbid with depressive symptoms.HUMAN BRAIN MAPPING,42(6),1617-1625. |
MLA | Wei, Gao-Xia,et al."Structural abnormalities of cingulate cortex in patients with first-episode drug-naive schizophrenia comorbid with depressive symptoms".HUMAN BRAIN MAPPING 42.6(2020):1617-1625. |
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