Altered grey matter volume and white matter integrity in individuals with high schizo-obsessive traits, high schizotypal traits and obsessive-compulsive symptoms

doi:10.1016/j.ajp.2020.102096

CORC > 心理研究所 > 中国科学院心理研究所 > 中国科学院心理健康重点实验室

	Altered grey matter volume and white matter integrity in individuals with high schizo-obsessive traits, high schizotypal traits and obsessive-compulsive symptoms
	Wang, Yong-ming 1,4,5,6; Zhang, Yi-jing 1,4; Cai, Xin-lu 1,4,5,6; Yang, Han-xue 1,4; Shan, Hai-di 3; Cheung, Eric F. C.2; Chan, Raymond C. K.1,4,5,6
刊名	ASIAN JOURNAL OF PSYCHIATRY
	2020-08-01
卷号	52 页码:6
关键词	Schizo-obsessive traits Schizotypal traits Obsessive-Compulsive Symptoms Grey matter volume White matter integrity
ISSN号	1876-2018
DOI	10.1016/j.ajp.2020.102096
通讯作者	Chan, Raymond C. K.(rckchan@psych.ac.cn)
英文摘要	Altered brain structures have been found in patients with schizo-obsessive disorder, schizophrenia and obsessive-compulsive disorder in previous studies. However, it is unclear whether similar brain changes are also found in individuals with high schizo-obsessive traits (SOT), high schizotypal traits (SCT) and obsessive-compulsive symptoms (OCS). We examined grey matter volume (GMV) and white matter integrity (WMI, including fractional anisotropy, mean diffusivity, axial diffusivity and radial diffusivity) in 26 individuals with high SOT, 30 individuals with high SCT, 25 individuals with OCS and 30 individuals with low trait scores (LT) in this study. Correlation analysis between GMV, WMI, Schizotypal Personality Questionnaire (SPQ) scores and Obsessive-Compulsive Inventory-Revised (OCI-R) scores in the subclinical groups was also carried out. We found that the SOT group exhibited increased GMV at the right superior occipital gyrus and the left postcentral gyrus compared with the LT group. The SCT group exhibited increased GMV at the right precentral gyrus and the bilateral cuneus compared with the LT group, and decreased fractional anisotropy at the anterior corona radiata compared with the other three groups. The OCS group exhibited increased GMV at the left superior temporal gyrus and decreased GMV at the left pre-supplementary motor area compared with the LT group. These findings highlight specific brain changes in individuals with high SOT, high SCT and OCS, and may thus provide new insights into the neurobiological changes that occur in sub-clinical populations of these disorders.
资助项目	National Key Research and Development Programme[2016YFC0906402] ; Beijing Municipal Science & Technology Commission[Z161100000216138] ; Beijing Training Project for the Leading Talents in S T[Z151100000315020] ; CAS Key Laboratory of Mental Health, Institute of Psychology
WOS关键词	ANTERIOR CORONA RADIATA ; BRAIN STRUCTURE ; BDNF GENE ; HIGH-RISK ; SCHIZOPHRENIA ; METAANALYSIS ; DISORDER ; ASSOCIATION ; SPECTRUM ; NEUROBIOLOGY
WOS研究方向	Psychiatry
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000573651300004
资助机构	National Key Research and Development Programme ; Beijing Municipal Science & Technology Commission ; Beijing Training Project for the Leading Talents in S T ; CAS Key Laboratory of Mental Health, Institute of Psychology
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/32877]
专题	心理研究所_中国科学院心理健康重点实验室
通讯作者	Chan, Raymond C. K.
作者单位	1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 2.Castle Peak Hosp, Hong Kong, Peoples R China 3.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Translat Neuropsychol & Appl Cognit Neurosci Lab, Sch Med, Shanghai, Peoples R China 4.Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 5.Univ Chinese Acad Sci, Sino Danish Coll, Beijing 100190, Peoples R China 6.Sino Danish Ctr Educ & Res, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yong-ming,Zhang, Yi-jing,Cai, Xin-lu,et al. Altered grey matter volume and white matter integrity in individuals with high schizo-obsessive traits, high schizotypal traits and obsessive-compulsive symptoms[J]. ASIAN JOURNAL OF PSYCHIATRY,2020,52:6.
APA	Wang, Yong-ming.,Zhang, Yi-jing.,Cai, Xin-lu.,Yang, Han-xue.,Shan, Hai-di.,...&Chan, Raymond C. K..(2020).Altered grey matter volume and white matter integrity in individuals with high schizo-obsessive traits, high schizotypal traits and obsessive-compulsive symptoms.ASIAN JOURNAL OF PSYCHIATRY,52,6.
MLA	Wang, Yong-ming,et al."Altered grey matter volume and white matter integrity in individuals with high schizo-obsessive traits, high schizotypal traits and obsessive-compulsive symptoms".ASIAN JOURNAL OF PSYCHIATRY 52(2020):6.