The Neural Origin of Nociceptive-Induced Gamma-Band Oscillations | |
Yue, Lupeng2,4; Iannetti, G. D.1,3; Hu, Li2,4 | |
刊名 | JOURNAL OF NEUROSCIENCE
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2020-04-22 | |
卷号 | 40期号:17页码:3478-3490 |
关键词 | biomarkers gamma-band oscillations interneurons pain primary motor cortex primary somatosensory cortex |
ISSN号 | 0270-6474 |
DOI | 10.1523/JNEUROSCI.0255-20.2020 |
产权排序 | 1 |
文献子类 | article |
英文摘要 | Gamma-band oscillations (GBOs) elicited by transient nociceptive stimuli are one of the most promising biomarkers of pain across species. Still, whether these GBOs reflect stimulus encoding in the primary somatosensory cortex (Si) or nocifensive behavior in the primary motor cortex (Ml) is debated. Here we recorded neural activity simultaneously from the brain surface as well as at different depths of the bilateral Sl/MI in freely-moving male rats receiving nociceptive stimulation. GBOs measured from superficial layers of Si contralateral to the stimulated paw not only had the largest magnitude, but also showed the strongest temporal and phase coupling with epidural GBOs. Also, spiking of superficial SI interneurons had the strongest phase coherence with epidural GBOs. These results provide the first direct demonstration that scalp GBOs, one of the most promising pain biomarkers, reflect neural activity strongly coupled with the fast spiking of interneurons in the superficial layers of the Si contralateral to the stimulated side. |
资助项目 | National Natural Science Foundation of China[31822025] ; National Natural Science Foundation of China[31671141] ; Scientific Foundation Project of Institute of Psychology, Chinese Academy of Sciences[Y6CX021008] ; European Research Council (ERC Consolidator Grant PAINSTRAT) ; Wellcome Trust (COLL JLARAXR) |
WOS关键词 | PRIMARY SOMATOSENSORY CORTEX ; PYRAMIDAL NEURONS ; PAIN MATRIX ; RESPONSES ; REFLECT ; EEG ; CONNECTIVITY ; ISSUES ; SYNCHRONIZATION ; POTENTIALS |
WOS研究方向 | Neurosciences & Neurology |
语种 | 英语 |
出版者 | SOC NEUROSCIENCE |
WOS记录号 | WOS:000528267300012 |
资助机构 | National Natural Science Foundation of China ; Scientific Foundation Project of Institute of Psychology, Chinese Academy of Sciences ; European Research Council (ERC Consolidator Grant PAINSTRAT) ; Wellcome Trust (COLL JLARAXR) |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/31710] ![]() |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Hu, Li |
作者单位 | 1.UCL, Dept Neurosci Physiol & Pharmacol, London WC1E 6BT, England 2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 3.Ist Italiano Tecnol, Neurosci & Behav Lab, I-00161 Rome, Italy 4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China |
推荐引用方式 GB/T 7714 | Yue, Lupeng,Iannetti, G. D.,Hu, Li. The Neural Origin of Nociceptive-Induced Gamma-Band Oscillations[J]. JOURNAL OF NEUROSCIENCE,2020,40(17):3478-3490. |
APA | Yue, Lupeng,Iannetti, G. D.,&Hu, Li.(2020).The Neural Origin of Nociceptive-Induced Gamma-Band Oscillations.JOURNAL OF NEUROSCIENCE,40(17),3478-3490. |
MLA | Yue, Lupeng,et al."The Neural Origin of Nociceptive-Induced Gamma-Band Oscillations".JOURNAL OF NEUROSCIENCE 40.17(2020):3478-3490. |
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