Long-Term Efficacy of Deep Brain Stimulation of Bilateral Globus Pallidus Internus in Primary Meige Syndrome

doi:10.1159/000504861

CORC > 心理研究所 > 中国科学院心理研究所 > 中国科学院心理健康重点实验室

	Long-Term Efficacy of Deep Brain Stimulation of Bilateral Globus Pallidus Internus in Primary Meige Syndrome
	Tian, Hong 1; Yu, Yanbing 1; Zhen, Xueke 1; Zhang, Li 1; Yuan, Yue 1; Zhang, Bo 2; Wang, Liang 3,4
刊名	STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
	2019
卷号	97 期号:5-6 页码:356-361
关键词	Meige syndrome Deep brain stimulation Globus pallidus internus Clinical effects Long-term efficacy
ISSN号	1011-6125
DOI	10.1159/000504861
通讯作者	Yu, Yanbing(yyb5185@126.com) ; Wang, Liang(lwang@psych.ac.cn)
英文摘要	Objective: Deep brain stimulation (DBS) of the internal segment of the globus pallidus (GPi) is an alternative therapy in ameliorating the clinical symptoms of primary Meige syndrome. Nevertheless, proof of its efficacy and safety is insufficient due to several case reports and small-sample clinical studies. This study aims to investigate postoperative long-term efficacy in patients undergoing DBS of the GPi for primary Meige syndrome. Methods: We performed a retrospective study to assess the efficacy and safety of bilateral GPi stimulation in 40 patients with primary Meige syndrome who responded poorly to medical treatments or botulinum toxin injections. All participants were postoperatively followed up at the outpatient clinic, and their motor functions were assessed using the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS). The severity of patients' dystonia was evaluated before surgery and at follow-up neurostimu-lation. Results: The implanted stimulator was turned on 1 month after surgery. All 40 patients received monopolar stimulation using the following parameters: voltage 2.5-3.5 V (average: 2.6 +/- 0.8 V), frequency 60-160 Hz (average: 88.0 +/- 21.3 Hz), and pulse width 60-185 mu S (average: 90.0 +/- 21.1 mu S). In 28 of 40 patients, the symptoms had signifi-cantly improved within 1 week of stimulation. Most of the patients had been followed up for 6-24 months (average: 15.0 +/- 7.8 months). The clinical symptoms of all patients had significantly improved. At 6, 12, and 24 months after surgery, the BFMDRS subscores of eyes, mouth, speech, and swallowing were significantly lower, and subscores of mouth movement showed progressively decreased with prolonged stimulation time. The overall improvement rate was 83%. Five adverse events occurred in the 40 patients; all of these events resolved without permanent sequelae. Conclusions: Bilateral GPi-DBS demonstrated satisfactory long-term efficacy in the treatment of primary Meige syndrome and could serve as an effective and safe option.
资助项目	Strategic Priority Research Program of the Chinese Academy of Science[XDB32010300] ; Beijing Municipal Science and Technology Commission[Z171100000117014] ; CAS Interdisciplinary Innovation Team[JCTD-2018-07] ; Natural Science Foundation of China[31771255]
WOS关键词	DYSTONIA ; BLEPHAROSPASM
WOS研究方向	Neurosciences & Neurology ; Surgery
语种	英语
出版者	KARGER
WOS记录号	WOS:000516593300008
资助机构	Strategic Priority Research Program of the Chinese Academy of Science ; Beijing Municipal Science and Technology Commission ; CAS Interdisciplinary Innovation Team ; Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/31403]
专题	心理研究所_中国科学院心理健康重点实验室
通讯作者	Yu, Yanbing; Wang, Liang
作者单位	1.China Japan Friendship Hosp, Dept Neurosurg, Beijing 100029, Peoples R China 2.Zunyi Med Univ, Key Lab Brain Sci, Zunyi, Guizhou, Peoples R China 3.Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Tian, Hong,Yu, Yanbing,Zhen, Xueke,et al. Long-Term Efficacy of Deep Brain Stimulation of Bilateral Globus Pallidus Internus in Primary Meige Syndrome[J]. STEREOTACTIC AND FUNCTIONAL NEUROSURGERY,2019,97(5-6):356-361.
APA	Tian, Hong.,Yu, Yanbing.,Zhen, Xueke.,Zhang, Li.,Yuan, Yue.,...&Wang, Liang.(2019).Long-Term Efficacy of Deep Brain Stimulation of Bilateral Globus Pallidus Internus in Primary Meige Syndrome.STEREOTACTIC AND FUNCTIONAL NEUROSURGERY,97(5-6),356-361.
MLA	Tian, Hong,et al."Long-Term Efficacy of Deep Brain Stimulation of Bilateral Globus Pallidus Internus in Primary Meige Syndrome".STEREOTACTIC AND FUNCTIONAL NEUROSURGERY 97.5-6(2019):356-361.