Neurobiological Mechanism of Drug-associated Memories and Its Clinic Intervention

doi:10.16476/j.pibb.2019.0079

CORC > 心理研究所 > 中国科学院心理研究所 > 中国科学院心理健康重点实验室

	Neurobiological Mechanism of Drug-associated Memories and Its Clinic Intervention
	Liu Wang 1,2; Chen Qiao 1,2; Li Yong-Hui 1,2
刊名	PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
	2019-10-01
卷号	46 期号:10 页码:941-951
关键词	drug-associated memories neurobiological mechanism extinction training memory reconsolidation virtual reality neuromodulation
ISSN号	1000-3282
DOI	10.16476/j.pibb.2019.0079
通讯作者	Li Yong-Hui(liyonghui@pscy.ac.cn)
英文摘要	Relapse behavior after long-term abstinence is the key problem of addiction treatment. A major factor to induce relapse is the persistence of maladaptive drug-associated memories. Persistent changes in structure and function of prefrontal cortex-mesolimbic dopamine system caused by chronic drug abusing, lead to the formation of pathological drug-associated memories. This article reviews addiction with a focus on how it can be conceptualised as a disorder of maladaptive memory, considering the neural basis of drug-associated memories during the initial phase, the habituation phase and the maintenance phase of addictive behavior. The present review summarizes the clinical intervention methods of drug-associated memories in recent years including extinction training, extinction in multiple contexts to facilitate extinction and reconsolidation intervention to disrupt drug-associated memories directly, and the application of virtual reality technology and neuromodulation methods in addiction intervention. The intervention methods combined memory reconsolidation with virtual reality technology or neuromodulation methods are prospected to target drug-associated memories, providing new methods and new ideas to treat addiction in future clinical researches.
资助项目	National Key Research and Development Program of China[2017YFC1310405] ; National Key Research and Development Program of China[2016YFC0800907] ; National Natural Science Foundation of China[U1736124] ; CAS Key Lab of Mental Health
WOS关键词	DIRECT-CURRENT STIMULATION ; DEEP BRAIN-STIMULATION ; CUE-EXPOSURE THERAPY ; POST-RETRIEVAL EXTINCTION ; MEDIAL PREFRONTAL CORTEX ; COCAINE-SEEKING ; NUCLEUS-ACCUMBENS ; INDUCED REINSTATEMENT ; BASOLATERAL AMYGDALA ; VIRTUAL-REALITY
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
语种	英语
出版者	CHINESE ACAD SCIENCES, INST BIOPHYSICS
WOS记录号	WOS:000492109100001
资助机构	National Key Research and Development Program of China ; National Natural Science Foundation of China ; CAS Key Lab of Mental Health
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/30756]
专题	心理研究所_中国科学院心理健康重点实验室
通讯作者	Li Yong-Hui
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Liu Wang,Chen Qiao,Li Yong-Hui. Neurobiological Mechanism of Drug-associated Memories and Its Clinic Intervention[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2019,46(10):941-951.
APA	Liu Wang,Chen Qiao,&Li Yong-Hui.(2019).Neurobiological Mechanism of Drug-associated Memories and Its Clinic Intervention.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,46(10),941-951.
MLA	Liu Wang,et al."Neurobiological Mechanism of Drug-associated Memories and Its Clinic Intervention".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 46.10(2019):941-951.