pH-Responsive metal-organic framework encapsulated gold nanoclusters with modulated release to enhance photodynamic therapy/chemotherapy in breast cancer

doi:10.1039/c9tb02621e

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	pH-Responsive metal-organic framework encapsulated gold nanoclusters with modulated release to enhance photodynamic therapy/chemotherapy in breast cancer
	Zhang, Luyun ; Gao, Yang ; Sun, Sijia ; Li, Zihou ; Wu, Aiguo ; Zeng, Leyong
刊名	JOURNAL OF MATERIALS CHEMISTRY B
	2020
卷号	8 期号:8 页码:1739-1747
关键词	IN-VITRO DELIVERY NANOPROBES NANOPARTICLES THERAPY ZIF-8
DOI	10.1039/c9tb02621e
英文摘要	Gold nanoclusters (AuNCs) with an ultra-small size, as new inorganic photosensitizers, have been shown to be promising in photodynamic therapy (PDT), but their application has been restricted due to short blood circulation. It is therefore important to develop stimuli-responsive AuNC-based nanoprobes to achieve highly efficient PDT. Here, metal-organic framework (MOF, ZIF-8) encapsulated AuNCs (AuNCs@MOF) were synthesized, and then they were loaded with doxorubicin (DOX) to obtain pH-responsive nanoprobes (AuNCs@MOF-DOX) with modulated release for enhanced PDT/chemotherapy. In an acidic tumor microenvironment, the structure of ZIF-8 collapsed, accelerating the release of the AuNCs and DOX in the tumor cells, and enhancing the performance of PDT/chemotherapy. Under irradiation with a 670 nm laser, a large amount of singlet oxygen was generated, and the release rate of DOX increased to 77.1% at a pH value of 5.5. By single PDT and single chemotherapy, the tumors were only partially inhibited, but they completely disappeared using the combination of PDT and chemotherapy. The prepared pH-responsive AuNCs@MOF-DOX nanoprobes with modulated release showed excellent PDT/chemotherapy performance, and will be important bi-functional nanoprobes for synergistic therapy.
学科主题	Materials Science
内容类型	期刊论文
源URL	[http://ir.nimte.ac.cn/handle/174433/19939]
专题	2020专题
作者单位	1.Zeng, LY (corresponding author), Hebei Univ, Key Lab Med Chem & Mol Diag, Minist Educ, Coll Chem & Environm Sci,Chem Biol Key Lab Hebei, Baoding 071002, Peoples R China. 2.Wu, AG (corresponding author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Cixi Inst Biomed Engn, CAS Key Lab Magnet Mat & Devices, Ningbo 315201, Peoples R China. 3.Wu, AG (corresponding author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Key Lab Addit Mfg Mat Zhejiang Prov, Ningbo 315201, Peoples R China.
推荐引用方式 GB/T 7714	Zhang, Luyun,Gao, Yang,Sun, Sijia,et al. pH-Responsive metal-organic framework encapsulated gold nanoclusters with modulated release to enhance photodynamic therapy/chemotherapy in breast cancer[J]. JOURNAL OF MATERIALS CHEMISTRY B,2020,8(8):1739-1747.
APA	Zhang, Luyun,Gao, Yang,Sun, Sijia,Li, Zihou,Wu, Aiguo,&Zeng, Leyong.(2020).pH-Responsive metal-organic framework encapsulated gold nanoclusters with modulated release to enhance photodynamic therapy/chemotherapy in breast cancer.JOURNAL OF MATERIALS CHEMISTRY B,8(8),1739-1747.
MLA	Zhang, Luyun,et al."pH-Responsive metal-organic framework encapsulated gold nanoclusters with modulated release to enhance photodynamic therapy/chemotherapy in breast cancer".JOURNAL OF MATERIALS CHEMISTRY B 8.8(2020):1739-1747.