Small-sized gadolinium oxide based nanoparticles for high-efficiency theranostics of orthotopic glioblastoma

doi:10.1016/j.biomaterials.2020.119783

CORC > 宁波材料技术与工程研究所 > 中国科学院宁波材料技术与工程研究所 > 2020专题

	Small-sized gadolinium oxide based nanoparticles for high-efficiency theranostics of orthotopic glioblastoma
	Shen, Zheyu ; Liu, Ting ; Yang, Zhen ; Zhou, Zijian ; Tang, Wei ; Fan, Wenpei ; Liu, Yijing ; Mu, Jing ; Li, Ling ; Bregadze, Vladimir, I
刊名	BIOMATERIALS
	2020
卷号	235
关键词	BLOOD-BRAIN-BARRIER CONTRAST AGENTS GOLD NANOPARTICLES DRUG-DELIVERY BEVACIZUMAB THERAPY T-1 PERMEABILITY RADIOTHERAPY TEMOZOLOMIDE
DOI	10.1016/j.biomaterials.2020.119783
英文摘要	Glioblastoma (GBM) is one of the most malignant tumors with poor prognosis and outcomes. Although smaller particle size can lead to higher blood-brain barrier (BBB)-permeability of the nanomaterials, most of the reported BBB-crossable nanomaterials for targeted GBM therapy are larger than 24 nm. To realize theranostics of GBM, co-loading of therapeutic and diagnostic agents on the same nanomaterials further results in larger particle size. In this study, we developed a kind of novel BBB-transportable nanomaterials smaller than 14 nm for high-efficiency theranostics of GBM (i.e., high contrast magnetic resonance imaging (MRI) and radiosensitization of GBM). Typically, poly(acrylic acid) (PAA) stabilized extremely small gadolinium oxide nanoparticles with modification of reductive bovine serum albumin (ES-GON-rBSA) was synthesized in water phase, resulting in excellent water-dispersibility. RGD dimer (RGD2, Glu-{Cyclo[Arg-Gly-Asp-(D-Phe)-Lys]}(2)) and lactoferrin (LF) were then conjugated to the ES-GON-rBSA to obtain composite nanoparticle ES-GON-rBSA-LF-RGD2 with extraordinary relaxivities (r(1) = 60.8 mM(-1) s(-1), r(2)/r(1) = 1.1). The maximum signal enhancement (Delta SNR) for T-1-weighted MRI of tumors reached up to 423 +/- 42% at 12 h post-injection of ES-GON-rBSA-LF-RGD2, which is much higher than commercial Gd-chelates (<80%). ES-GON-rBSA-LF-RGD2 exhibited high biocompatibility and can transport across the in vitro BBB model and the in vivo BBB of mice due to its small particle size (d(h) = 13.4 nm) and LF receptor mediated transcytosis. Orthotopic GBM studies reinforce that ES-GON-rBSA3-LF-RGD2 can accumulate in the orthotopic GBM and enhance the radiation therapy of GBM as an effective radiosensitizing agent.
学科主题	Engineering ; Materials Science
内容类型	期刊论文
源URL	[http://ir.nimte.ac.cn/handle/174433/19919]
专题	2020专题
作者单位	1.Fan, WP (corresponding author), China Pharmaceut Univ, Ctr Adv Pharmaceut & Biomat, Jiangsu Key Lab Drug Discovery Metab Dis, Nanjing 210009, Peoples R China. 2.Wu, AG (corresponding author), Chinese Acad Sci, Cixi Inst Biomed Engn, Ningbo Inst Mat Technol & Engn, CAS Key Lab Magnet Mat & Devices,Key Lab Addit Mf, 1219 Zhong Guan West Rd, Ningbo 315201, Zhejiang, Peoples R China. 3.Chen, XY (corresponding author), Natl Inst Biomed Imaging & Bioengn, Lab Mol Imaging & Nemomed, Bethesda, MD 20892 USA. 4.Qiu, XZ (corresponding author), Southern Med Univ, Biomat Res Ctr, Sch Biomed Engn, Guangdong Prov Key Lab Construct & Detect Tissue, Guangzhou 510515, Peoples R China. 5.Fan, WP (corresponding author), China Pharmaceut Univ, Ctr Adv Pharmaceut & Biomat, State Key Lab Nat Med, Nanjing 210009, Peoples R China.
推荐引用方式 GB/T 7714	Shen, Zheyu,Liu, Ting,Yang, Zhen,et al. Small-sized gadolinium oxide based nanoparticles for high-efficiency theranostics of orthotopic glioblastoma[J]. BIOMATERIALS,2020,235.
APA	Shen, Zheyu.,Liu, Ting.,Yang, Zhen.,Zhou, Zijian.,Tang, Wei.,...&Chen, Xiaoyuan.(2020).Small-sized gadolinium oxide based nanoparticles for high-efficiency theranostics of orthotopic glioblastoma.BIOMATERIALS,235.
MLA	Shen, Zheyu,et al."Small-sized gadolinium oxide based nanoparticles for high-efficiency theranostics of orthotopic glioblastoma".BIOMATERIALS 235(2020).