Therapeutic drugs for SARS-CoV-2 treatment: Current state and perspective

doi:10.1016/j.intimp.2020.107228

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	Therapeutic drugs for SARS-CoV-2 treatment: Current state and perspective
	Bolarin, Joshua Adedeji 9,10; Oluwatoyosi, Mercy Adaramodu 9,11; Orege, Joshua Iseoluwa 9,10; Ayeni, Emmanuel Ayodeji 1,9; Ibrahim, Yusuf Ajibola 2,9; Adeyemi, Sherif Babatunde 3; Tiamiyu, Bashir Bolaji 4,9; Gbadegesin, Lanre Anthony 5,9; Akinyemi, Toluwanimi Oluwadara 6,9; Odoh, Chuks Kenneth 9,10
刊名	INTERNATIONAL IMMUNOPHARMACOLOGY
	2021
卷号	90 页码:19
关键词	COVID-19 Therapeutics Drug interaction Antiviral drugs Health and safety
ISSN号	1567-5769
DOI	10.1016/j.intimp.2020.107228
通讯作者	Ayeni, Emmanuel Ayodeji(ayeniemmanuel11@mails.ucas.ac.cn)
英文摘要	The disease caused by viral pneumonia called severe acute respiratory syndrome coronavirus type-2 (SARS-CoV2) declared by the World Health Organization is a global pandemic that the world has witnessed since the last Ebola epidemic, SARS and MERS viruses. Many chemical compounds with antiviral activity are currently undergoing clinical investigation in order to find treatments for SARS-CoV-2 infected patients. On-going drug-drug interaction examinations on new, existing, and repurposed antiviral drugs are yet to provide adequate safety, toxicological, and effective monitoring protocols. This review presents an overview of direct and indirect antiviral drugs, antibiotics, and immune-stimulants used in the management of SARS-CoV-2. It also seeks to outline the recent development of drugs with anti-coronavirus effects; their mono and combination therapy in managing the disease vis -`a-vis their biological sources and chemistry. Co-administration of these drugs and their interactions were discussed to provide significant insight into how adequate monitoring of patients towards effective health management could be achieved.
WOS关键词	SARS CORONAVIRUS INFECTION ; GLYCOPEPTIDE ANTIBIOTICS ; MERS-COV ; IN-VITRO ; POTENT INHIBITOR ; EBOLA-VIRUS ; CHLOROQUINE ; COLCHICINE ; COVID-19 ; RNA
WOS研究方向	Immunology ; Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000611870100001
内容类型	期刊论文
源URL	[http://ir.imde.ac.cn/handle/131551/55936]
专题	中国科学院水利部成都山地灾害与环境研究所
通讯作者	Ayeni, Emmanuel Ayodeji
作者单位	1.Chinese Acad Sci, Chengdu Inst Biol, Chengdu Pmb 610041, Sichuan, Peoples R China 2.Chinese Acad Sci, Sch Chem Sci, Beijing, Peoples R China 3.Uka Tarsadia Univ, CG Bhakta Inst Biotechnol, Bardoli, Gujarat, India 4.Chinese Acad Sci, Wuhan Bot Garden, Wuhan, Peoples R China 5.Chinese Acad Sci, Inst Mt Hazards & Environm, Beijing, Peoples R China 6.Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen, Peoples R China 7.Chinese Acad Sci, Inst Rock & Soil Mech, Wuhan, Peoples R China 8.Chinese Acad Sci, Inst Urban Environm, Xiamen, Peoples R China 9.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 10.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China
推荐引用方式 GB/T 7714	Bolarin, Joshua Adedeji,Oluwatoyosi, Mercy Adaramodu,Orege, Joshua Iseoluwa,et al. Therapeutic drugs for SARS-CoV-2 treatment: Current state and perspective[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2021,90:19.
APA	Bolarin, Joshua Adedeji.,Oluwatoyosi, Mercy Adaramodu.,Orege, Joshua Iseoluwa.,Ayeni, Emmanuel Ayodeji.,Ibrahim, Yusuf Ajibola.,...&Adeoye, Adenike Bernice-Eloise.(2021).Therapeutic drugs for SARS-CoV-2 treatment: Current state and perspective.INTERNATIONAL IMMUNOPHARMACOLOGY,90,19.
MLA	Bolarin, Joshua Adedeji,et al."Therapeutic drugs for SARS-CoV-2 treatment: Current state and perspective".INTERNATIONAL IMMUNOPHARMACOLOGY 90(2021):19.