Synthesis of Novel Chitin Derivatives Bearing Amino Groups and Evaluation of Their Antifungal Activity

doi:10.3390/md16100380

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室 > 海岸带生物资源高效利用研究与发展中心

	Synthesis of Novel Chitin Derivatives Bearing Amino Groups and Evaluation of Their Antifungal Activity
	Zhang, Jingjing ; Luan, Fang ; Li, Qing ; Gu, Guodong ; Dong, Fang ; Guo, Zhanyong
刊名	MARINE DRUGS
	2018-10
卷号	16 期号:10 页码:380
关键词	6-amino-chitin 3,6-diamino-chitin antifungal activity chitin derivative structure characteristics
ISSN号	1660-3397
DOI	10.3390/md16100380
产权排序	[Zhang, Jingjing ; Li, Qing ; Dong, Fang ; Guo, Zhanyong] Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China ; [Zhang, Jingjing ; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China ; [Luan, Fang] Shandong Jiaotong Univ, Nav Coll, Weihai 264209, Peoples R China ; [Gu, Guodong] Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA
文献子类	Article
英文摘要	Chemical modification is one of the most effective methods to improve the biological activity of chitin. In the current study, we modified C3-OH and C6-OH of chitin (CT) and successfully synthesized 6-amino-chitin (NCT) and 3,6-diamino-chitin (DNCT) through a series of chemical reactions. The structure of NCT and DNCT were characterized by elemental analyses, FT-IR, C-13 NMR, XRD, and SEM. The inhibitory effects of CT, NCT, and DNCT against six kinds of phytopathogen (F. oxysporum f. sp. cucumerium, B. cinerea, C. lagenarium, P. asparagi, F. oxysporum f. niveum, and G. zeae) were evaluated using disk diffusion method in vitro. Meanwhile, carbendazim and amphotericin B were used as positive controls. Results revealed that 6-amino-chitin (NCT) and 3,6-diamino-chitin (DNCT) showed improved antifungal properties compared with pristine chitin. Moreover, DNCT exhibited the better antifungal property than NCT. Especially, while the inhibition zone diameters of NCT are ranged from 11.2 to 16.3 mm, DNCT are about 11.4-20.4 mm. These data demonstrated that the introduction of amino group into chitin derivatives could be key to increasing the antifungal activity of such compounds, and the greater the number of amino groups in the chitin derivatives, the better their antifungal activity was.
WOS关键词	CHITOSAN DERIVATIVES ; IN-VITRO ; ANTIOXIDANT ACTIVITIES ; ANTIBACTERIAL ACTIVITY ; EXTRACTION ; PRODUCTS ; 6-AMINO-6-DEOXYCHITOSAN ; NANOPARTICLES ; PRECURSORS ; INULIN
WOS研究方向	Chemistry, Medicinal
语种	英语
WOS记录号	WOS:000448819600038
资助机构	Yantai Science and Technology Development Plan [2015ZH078] ; Technology Research Funds Projects of Ocean [2015418022-3] ; National Natural Science Foundation of China [41576156] ; Shandong Province Science and Technology Development Plan [2015GSF121045]
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/24545]
专题	海岸带生物资源高效利用研究与发展中心烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室烟台海岸带研究所_污染过程与控制实验室
作者单位	1.Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 3.Shandong Jiaotong Univ, Nav Coll, Weihai 264209, Peoples R China; 4.Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA
推荐引用方式 GB/T 7714	Zhang, Jingjing,Luan, Fang,Li, Qing,et al. Synthesis of Novel Chitin Derivatives Bearing Amino Groups and Evaluation of Their Antifungal Activity[J]. MARINE DRUGS,2018,16(10):380.
APA	Zhang, Jingjing,Luan, Fang,Li, Qing,Gu, Guodong,Dong, Fang,&Guo, Zhanyong.(2018).Synthesis of Novel Chitin Derivatives Bearing Amino Groups and Evaluation of Their Antifungal Activity.MARINE DRUGS,16(10),380.
MLA	Zhang, Jingjing,et al."Synthesis of Novel Chitin Derivatives Bearing Amino Groups and Evaluation of Their Antifungal Activity".MARINE DRUGS 16.10(2018):380.