Novel Water Soluble Chitosan Derivatives with 1,2,3-Triazolium and Their Free Radical-Scavenging Activity

doi:10.3390/md16040107

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室 > 海岸带生物资源高效利用研究与发展中心

	Novel Water Soluble Chitosan Derivatives with 1,2,3-Triazolium and Their Free Radical-Scavenging Activity
	Li, Qing ; Sun, Xueqi ; Gu, Guodong ; Guo, Zhanyong
刊名	MARINE DRUGS
	2018-04
卷号	16 期号:4 页码:UNSP 107
关键词	chitosan derivatives 1,2,3-triazolium free radical-scavenging activity
ISSN号	1660-3397
DOI	10.3390/md16040107
产权排序	[Li, Qing ; Sun, Xueqi ; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China ; [Sun, Xueqi] Grad Sch Chinese Acad Sci, Beijing 100039, Peoples R China ; [Gu, Guodong] Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA
文献子类	Article
英文摘要	Chitosan is an abundant and renewable polysaccharide, which exhibits attractive bioactivities and natural properties. Improvement such as chemical modification of chitosan is often performed for its potential of providing high bioactivity and good water solubility. A new class of chitosan derivatives possessing 1,2,3-triazolium charged units by associating "click reaction" with efficient 1,2,3-triazole quaternization were designed and synthesized. Their free radical-scavenging activity against three free radicals was tested. The inhibitory property and water solubility of the synthesized chitosan derivatives exhibited a remarkable improvement over chitosan. It is hypothesized that triazole or triazolium groups enable the synthesized chitosan to possess obviously better radical-scavenging activity. Moreover, the scavenging activity against superoxide radical of chitosan derivatives with triazolium (IC50 < 0.01 mg mL(-1)) was more efficient than that of derivatives with triazole and Vitamin C. In the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and hydroxyl radical-scavenging assay, the same pattern were observed, which should be related to the triazolium grafted at the periphery of molecular chains.
WOS关键词	ANTIFUNGAL ACTIVITY ; ANTIBACTERIAL ACTIVITY ; ANTIOXIDANT PROPERTIES ; QUATERNIZED CHITOSAN ; INULIN DERIVATIVES ; ANTITUMOR-ACTIVITY ; CLICK CHEMISTRY ; 1,2,4-TRIAZOLES ; DESIGN ; INHIBITORS
WOS研究方向	Chemistry, Medicinal
语种	英语
WOS记录号	WOS:000431068000009
资助机构	National Natural Science Foundation of China [41576156] ; Natural Science Foundation of Shandong Province of China [ZR2017BD015] ; Yantai Science and Technology Development Plan [2015ZH078] ; Technology Research Funds Projects of Ocean [2015418022-3]
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/24491]
专题	海岸带生物资源高效利用研究与发展中心烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China; 2.Grad Sch Chinese Acad Sci, Beijing 100039, Peoples R China; 3.Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA
推荐引用方式 GB/T 7714	Li, Qing,Sun, Xueqi,Gu, Guodong,et al. Novel Water Soluble Chitosan Derivatives with 1,2,3-Triazolium and Their Free Radical-Scavenging Activity[J]. MARINE DRUGS,2018,16(4):UNSP 107.
APA	Li, Qing,Sun, Xueqi,Gu, Guodong,&Guo, Zhanyong.(2018).Novel Water Soluble Chitosan Derivatives with 1,2,3-Triazolium and Their Free Radical-Scavenging Activity.MARINE DRUGS,16(4),UNSP 107.
MLA	Li, Qing,et al."Novel Water Soluble Chitosan Derivatives with 1,2,3-Triazolium and Their Free Radical-Scavenging Activity".MARINE DRUGS 16.4(2018):UNSP 107.