Synthesis of Novel Amino Lactose and Evaluation of Its Antioxidant Property

doi:10.1002/star.201700293

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室 > 海岸带生物资源高效利用研究与发展中心

	Synthesis of Novel Amino Lactose and Evaluation of Its Antioxidant Property
	Li, Qing ; Feng, Yan ; Gu, Guodong ; Guo, Zhanyong
刊名	STARCH-STARKE
	2018-05
卷号	70 期号:5-6 页码:1700293
关键词	amino lactose antioxidant activity chemical modifications
ISSN号	0038-9056
DOI	10.1002/star.201700293
产权排序	[Li, Qing ; Feng, Yan ; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China ; [Feng, Yan ; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China ; [Gu, Guodong] Alliance Pharma Inc, 17 Lee Blvd Malvern, Malvern, PA 19355 USA
文献子类	Article
英文摘要	In order to improve the bioactivity of lactose, a novel lactose derivative is designed and synthesized by introducing an amino group to the C-6 of lactose. The in vitro antioxidant activities of synthesized lactose derivatives are assessed. It shows better scavenging activity against hydrogen peroxide (IC50<0.1mgmL(-1)), hydroxyl radicals (IC50 0.55mgmL(-1)), and DPPH radicals (IC50 0.37mgmL(-1)) than lactose. Based on this data, it is reasonable to propose that the introduction of amino group through chemical modification is significant to enhance the free antioxidant activity of lactose. This derivatization strategy might provide an effective tool to broaden utilization of lactose.
WOS关键词	ANTIFUNGAL ACTIVITY ; CHITOSAN DERIVATIVES ; INULIN DERIVATIVES ; DRUG-RELEASE ; STARCH ; FILMS ; POLYSACCHARIDE ; AMYLASE ; DESIGN ; IMPACT
WOS研究方向	Food Science & Technology
语种	英语
WOS记录号	WOS:000431735200022
资助机构	Yantai Science and Technology Development Plan [2015ZH078] ; Public Science and Technology Research Funds Projects of Ocean [201505022-3] ; Natural Science Foundation of Shandong Province of China [ZR2017BD015] ; National Natural Science Foundation of China [41576156]
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/24477]
专题	海岸带生物资源高效利用研究与发展中心烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 3.Alliance Pharma Inc, 17 Lee Blvd Malvern, Malvern, PA 19355 USA
推荐引用方式 GB/T 7714	Li, Qing,Feng, Yan,Gu, Guodong,et al. Synthesis of Novel Amino Lactose and Evaluation of Its Antioxidant Property[J]. STARCH-STARKE,2018,70(5-6):1700293.
APA	Li, Qing,Feng, Yan,Gu, Guodong,&Guo, Zhanyong.(2018).Synthesis of Novel Amino Lactose and Evaluation of Its Antioxidant Property.STARCH-STARKE,70(5-6),1700293.
MLA	Li, Qing,et al."Synthesis of Novel Amino Lactose and Evaluation of Its Antioxidant Property".STARCH-STARKE 70.5-6(2018):1700293.