New sesquiterpenoids with COX-2 inhibitory activity from the medical plant Physalis. alkekengi L. var. franchetii

doi:10.1016/j.fitote.2020.104470

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中科院烟台海岸带研究所知识产出

	New sesquiterpenoids with COX-2 inhibitory activity from the medical plant Physalis. alkekengi L. var. franchetii
	Zhang, Jian-Long ; Zhou, Feng-Feng ; Li, You-Zhi ; Feng, Tao ; Jiang, Lin-Lin ; Jiang, Ren-Wang ; Zhang, Xing-Xiao ; Li, Xiao-Dong
刊名	FITOTERAPIA
	2020-03
卷号	141 页码:104470
关键词	ANGULATA WITHANOLIDES
DOI	10.1016/j.fitote.2020.104470
产权排序	[Zhang, Jian-Long ; Jiang, Lin-Lin ; Zhang, Xing-Xiao ; Li, Xiao-Dong] Ludong Univ, Sch Life Sci, Yantai 264025, Peoples R China ; [Zhang, Jian-Long ; Li, You-Zhi ; Feng, Tao ; Jiang, Lin-Lin] Shandong Prov Key Lab Qual Safty Monitoring & Ris, Jinan 250022, Peoples R China ; [Li, Xiao-Dong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China ; [Zhou, Feng-Feng] Linyi City People Hosp, Dept Infect Dis, Linyi 276000, Shandong, Peoples R China ; [Zhang, Jian-Long ; Jiang, Ren-Wang] Jinan Univ, Coll Pharm, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Peoples R China
文献子类	Article
英文摘要	Phytochemical investigations on Physalis. alkekengi L. var. franchetii, a widespread traditional Chinese medicine, led to the isolation and identification of three new sesquiterpenoids physalisitins A-C (1-3). Their structures were elucidated by NMR and HRESIMS analysis, and their absolute configurations were determined by quantum chemical NMR and ECD calculations, as well as by comparing their optical rotation values with those known analogues. All of the isolated compounds were evaluated for their cyclooxygenase-2 (COX-2) inhibitory activity. Compounds 1-3 dose-dependently inhibited the COX-2 enzyme with IC50 values of 3.22 +/- 0.25, 6.35 +/- 0.84, and 11.13 +/- 1.47 mu M, respectively.
WOS关键词	ANGULATA ; WITHANOLIDES
语种	英语
WOS记录号	WOS:000518703900013
资助机构	National Key Research and Development Program of China [2016YFD0501010, 2017YFD-0500806, 2018YFD0501402] ; Key Research and Development Program of Shandong Province [2017NC210009, 2019GSF107091] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81600672] ; Major Agricultural Applied Technological Innovation Projects of Shandong Province ; Key Research and Development Plan of Yantai [2018XSCC045] ; Innovation Team Project for Modem Agricultural Industrious Technology System of Shandong Province [SDAIT-11-10]
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/25082]
专题	烟台海岸带研究所_中科院烟台海岸带研究所知识产出
作者单位	1.Ludong Univ, Sch Life Sci, Yantai 264025, Peoples R China; 2.Jinan Univ, Coll Pharm, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Peoples R China 3.Linyi City People Hosp, Dept Infect Dis, Linyi 276000, Shandong, Peoples R China; 4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; 5.Shandong Prov Key Lab Qual Safty Monitoring & Ris, Jinan 250022, Peoples R China;
推荐引用方式 GB/T 7714	Zhang, Jian-Long,Zhou, Feng-Feng,Li, You-Zhi,et al. New sesquiterpenoids with COX-2 inhibitory activity from the medical plant Physalis. alkekengi L. var. franchetii[J]. FITOTERAPIA,2020,141:104470.
APA	Zhang, Jian-Long.,Zhou, Feng-Feng.,Li, You-Zhi.,Feng, Tao.,Jiang, Lin-Lin.,...&Li, Xiao-Dong.(2020).New sesquiterpenoids with COX-2 inhibitory activity from the medical plant Physalis. alkekengi L. var. franchetii.FITOTERAPIA,141,104470.
MLA	Zhang, Jian-Long,et al."New sesquiterpenoids with COX-2 inhibitory activity from the medical plant Physalis. alkekengi L. var. franchetii".FITOTERAPIA 141(2020):104470.