Determination of the antibiotic minocycline by integrated optofluidic microstructured polymer optical fiber chemiluminescence | |
Li, Zhanao5; Yang, Xinghua5; Teng, Pingping5; Kong, Depeng1; Gao, Shuai5; Liu, Zhihai5; Yang, Jun3,5; Gao, Danheng5; Luo, Meng5; Wen, Xingyue5 | |
刊名 | Instrumentation Science and Technology |
关键词 | Microstructured polymer optical fiber chemiluminescence in-fiber optofluidic device antibiotics minocycline |
ISSN号 | 10739149;15256030 |
DOI | 10.1080/10739149.2021.1912761 |
产权排序 | 2 |
英文摘要 | An in-fiber optofluidic chemiluminescence (CL) device is reported based on a low-cost microstructured polymer optical fiber (mPOF). The mPOF is composed of a central hole for liquid delivery and a suspended core for optical coupling. Due to the lower processing temperature of mPOF, the difficulty of constructing microfluidic channels is greatly reduced. In addition, the large core diameter of mPOF is more conducive to optical coupling. The microholes are opened on the surface of the mPOF by partial melting to complete the construction of the microfluidic channel. Simultaneously, the response of the CL reaction is detected on-line by the optoelectronic device. Minocycline (MC) was employed as the analyte for on-line optofluidic CL detection. The results show that the device detects aqueous minocycline from 0.0001 to 0.1 g/L with a linear response between 0.001 and 0.01 g/L. The limit of detection is 0.0001 g/L. Moreover, the ability of the device to detect minocycline in blood serum is investigated. The relative deviation from the linear calibration value is within 3.2%. Furthermore, the low-cost in-fiber optofluidic CL device may be integrated with other devices and offers potential in drug safety and medical detection. © 2021 Taylor & Francis Group, LLC. |
语种 | 英语 |
出版者 | Bellwether Publishing, Ltd. |
WOS记录号 | WOS:000640166100001 |
内容类型 | 期刊论文 |
源URL | [http://ir.opt.ac.cn/handle/181661/94695] |
专题 | 西安光学精密机械研究所_信息光子学研究室 |
通讯作者 | Yang, Xinghua; Teng, Pingping |
作者单位 | 1.State Key Laboratory of Transient Optics and Photonics, Xi’an Institute of Optics and precision Mechanic, Chinese Academy of Sciences, Xi’an, China; 2.Photonics Research Center, Guilin University of Electronics Technology, Guilin, China; 3.Guangdong Provincial Key Laboratory of Photonics Information Technology, Advanced Institute of Photonic Technology and the School of Information Engineering of Guangdong University of Technology, Guangzhou, China; 4.Wireless & Optoelectronics Research & Innovation Centre, Faculty of Computing, Engineering & Science, University of South Wales, United Kingdom 5.Key Laboratory of In-Fiber Integrated Optics, Ministry of Education, College of Science, Harbin Engineering University, Harbin, China; |
推荐引用方式 GB/T 7714 | Li, Zhanao,Yang, Xinghua,Teng, Pingping,et al. Determination of the antibiotic minocycline by integrated optofluidic microstructured polymer optical fiber chemiluminescence[J]. Instrumentation Science and Technology. |
APA | Li, Zhanao.,Yang, Xinghua.,Teng, Pingping.,Kong, Depeng.,Gao, Shuai.,...&Copner, Nigel. |
MLA | Li, Zhanao,et al."Determination of the antibiotic minocycline by integrated optofluidic microstructured polymer optical fiber chemiluminescence".Instrumentation Science and Technology |
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