Oxygen Vacancy Defect-Induced Activity Enhancement of Gd Doping Magnetic Nanocluster for Oxygen Supplying Cancer Theranostics | |
Xu, Rui1,2,3; Xu, Zhaowei2; Si, Yuanchun1; Xing, Xin1; Li, Qingdong2,4; Xiao, Jianmin4; Wang, Bin2; Tian, Geng2; Zhu, Ling3; Wu, Zhengyan4 | |
刊名 | ACS APPLIED MATERIALS & INTERFACES |
2020-08-19 | |
卷号 | 12 |
关键词 | oxygen vacancy defects nanotheranostic agent catalytic activity MRI contrast enhancement oxygen self-supplement |
ISSN号 | 1944-8244 |
DOI | 10.1021/acsami.0c09952 |
通讯作者 | Zhu, Ling(zhuling1425@163.com) ; Wu, Zhengyan(zywu@ipp.ac.cn) ; Zhang, Guilong(glzhang@bzmc.edu.cn) |
英文摘要 | This work finds that Fe3O4 nanoclusters can rearrange by Gd doping and then self-assemble to a hollow magnetic nanocluster (HMNC), providing larger magnetic moments to obtain an excellent MRI capability and increasing the number of oxygen vacancies in HMNC. The hollow structure makes platinum(IV) prodrugs effectively load into HIVING. Second, plenty of oxygen vacancy defects can capture oxygen molecules, enhance the catalytic activity of HMNC, and then promote intracellular ROS generation. On the basis of this, a targeting iRGD-labeled HMNC nanosystem (iHMNCPt-O-2) is developed through loading oxygen molecules and platinum(IV) prodrugs for chemo- and chemodynamic therapy of cancer. This nanosystem shows an excellent response ability to weak acid and GSH, which can cause a series of cascade reactions in a cell. These cascade reactions are dramatically enhanced at the intracellular ROS level, cause mitochondria and DNA damage, and then induce cancer cell death. Besides, systemic delivery of iHMNCPt-O-2 significantly enhanced the MRI contrast signal of tumors and improved the quality of MR images, accurately diagnosing tumors. Therefore, this work provides a novel method for accelerating the Fenton-like reaction and enhancing the MRI capability and fabricates a promising "all-in-one" system to overwhelm the problems of cancer theranostic. |
资助项目 | Taishan Scholars Construction Engineering[tsqn20161047] ; Taishan Scholars Construction Engineering[tsqn201909144] ; Natural Science Foundation of Anhui Province[1808085MB38] ; National Natural Science Foundation of China[31771284] ; National Natural Science Foundation of China[81401518] ; National Natural Science Foundation of China[31430028] ; National Natural Science Foundation of China[81630019] ; Shandong Provincial Natural Science Foundation[ZR2016JL026] ; Key Research and Development Plan of Shandong Province[2018GSF118230] |
WOS关键词 | OVERCOME MULTIDRUG-RESISTANCE ; FENTON-LIKE DEGRADATION ; CHEMOTHERAPY ; GLUTATHIONE ; GENERATION ; MICROENVIRONMENT ; NANOPARTICLES ; THERAPY ; DAMAGE |
WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
语种 | 英语 |
出版者 | AMER CHEMICAL SOC |
WOS记录号 | WOS:000563074900010 |
资助机构 | Taishan Scholars Construction Engineering ; Natural Science Foundation of Anhui Province ; National Natural Science Foundation of China ; Shandong Provincial Natural Science Foundation ; Key Research and Development Plan of Shandong Province |
内容类型 | 期刊论文 |
源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/43057] |
专题 | 合肥物质科学研究院_中科院固体物理研究所 |
通讯作者 | Zhu, Ling; Wu, Zhengyan; Zhang, Guilong |
作者单位 | 1.Anhui Med Univ, Dept Dent Implant Ctr, Stomatol Hosp & Coll, Key Lab Oral Dis Res Anhui Prov, Hefei 230032, Peoples R China 2.Binzhou Med Univ, Sch Pharm, Key Lab Prescript Effect & Clin Evaluat State Adm, Yantai 264003, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Med, Dept Radiol, Shanghai Peoples Hosp 9, Shanghai 200001, Peoples R China 4.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Peoples R China |
推荐引用方式 GB/T 7714 | Xu, Rui,Xu, Zhaowei,Si, Yuanchun,et al. Oxygen Vacancy Defect-Induced Activity Enhancement of Gd Doping Magnetic Nanocluster for Oxygen Supplying Cancer Theranostics[J]. ACS APPLIED MATERIALS & INTERFACES,2020,12. |
APA | Xu, Rui.,Xu, Zhaowei.,Si, Yuanchun.,Xing, Xin.,Li, Qingdong.,...&Zhang, Guilong.(2020).Oxygen Vacancy Defect-Induced Activity Enhancement of Gd Doping Magnetic Nanocluster for Oxygen Supplying Cancer Theranostics.ACS APPLIED MATERIALS & INTERFACES,12. |
MLA | Xu, Rui,et al."Oxygen Vacancy Defect-Induced Activity Enhancement of Gd Doping Magnetic Nanocluster for Oxygen Supplying Cancer Theranostics".ACS APPLIED MATERIALS & INTERFACES 12(2020). |
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