Surface-enhanced Raman spectroscopy (SERS) has been widely applied to identify or detect illicit drugs, because of the ability for highly specific molecular fingerprint and independence of aqueous solutions impact. We summarize the progress in determination of illicit drugs using SERS, including trace illicit drugs, suspicious objects and drugs or their metabolites in real biological system (urine, saliva and so on). Even though SERS detection of illicit drugs in real samples still remains a huge challenge because of the complex unknown environment, the efficient sample separation and the improved hand-held Raman analyzer will provide the possibility to make SERS a practically analytical technique. Moreover, we put forward a prospective overview for future perspectives of SERS as a practical sensor for illicit drugs determination. Perhaps the review is not exhaustive, we expect to help researchers to understand the evolution and challenges in this field and further interest in promoting Raman and SERS as a practical analyzer for convenient and automated illicit drugs identification.