Genetically Predicted Circulating Level of C-Reactive Protein Is Not Associated With Prostate Cancer Risk

doi:10.3389/fonc.2020.545603

	Genetically Predicted Circulating Level of C-Reactive Protein Is Not Associated With Prostate Cancer Risk
	He, Chiyu 2; Qian, Yu 3; Liu, Bin 3; Yang, Shaoxue 4; Ye, Ding 3; Sun, Xiaohui 3; Chen, Tianhui 1; Mao, Yingying 3
刊名	FRONTIERS IN ONCOLOGY
	2020-10-14
卷号	10
关键词	C-reactive protein genome-wide association study Mendelian randomization prostate cancer single-nucleotide polymorphisms
ISSN号	2234-943X
DOI	10.3389/fonc.2020.545603
通讯作者	Chen, Tianhui(chenth@zjcc.org.cn) ; Mao, Yingying(myy@zcmu.edu.cn)
英文摘要	Background: Inconsistent findings from observational studies have reported that C-reactive protein (CRP) is likely associated with risk of prostate cancer. Because conventional observational studies are susceptible to confounding and reverse causality, it remains unclear whether there is a causal relationship of CRP with risk of prostate cancer. Methods: In this study, we applied a two-sample Mendelian randomization (MR) approach to evaluate the potential causal association of circulating CRP levels with prostate cancer risk. Instrumental variables (IVs) and corresponding genetic association estimates for circulating CRP levels were obtained from a meta-analysis of genome-wide association studies (GWASs) including 204,402 participants of European descent. The genetic association estimates of these IVs with prostate cancer were obtained from a GWAS meta-analysis including 79,148 cases and 61,106 controls of European ancestry. The inverse-variance weighted (IVW) method was used as primary MR analyses, whereas in sensitivity analyses, MR-Egger regression, and MR pleiotropy residual sum and outlier (MR-PRESSO) test were used to assess the presence of pleiotropy. Odd ratio (OR) and 95% CI were calculated. Results: Overall, 58 single-nucleotide polymorphisms were used as instruments for circulating CRP levels. MR analysis suggested that genetically determined CRP levels were not associated with prostate cancer risk (OR 1.06, 95% CI 0.96 to 1.16) using the IVW method. Sensitivity analyses using alternative MR methods produced similar results (OR 1.00, 95% CI 0.93 to 1.08 for the weighted-median method; OR 1.02, 95% CI 0.95 to 1.08 for MR-PRESSO test). MR-Egger regression did not suggest evidence of directional pleiotropy (P = 0.25). Conclusion: Our study found that genetically predicted circulating CRP levels were not associated with prostate cancer risk, suggesting that CRP is unlikely to be a causal factor in the development of prostate cancer.
资助项目	National Natural Science Foundation of China[81973663] ; National Natural Science Foundation of China[81602917] ; Natural Science Foundation of Zhejiang Province[LQ20H260008] ; Talent Project of Zhejiang Association for Science and Technology[2018YCGC003] ; Foundation of Zhejiang Chinese Medical University[KC201905] ; Foundation of Zhejiang Chinese Medical University[2020ZR09] ; Startup Funds for Recruited Talents at Zhejiang Cancer Hospital
WOS关键词	MENDELIAN RANDOMIZATION ; INFLAMMATORY MARKERS ; INSTRUMENTS ; INTERLEUKIN-6 ; PREVENTION ; HEALTH ; BIAS
WOS研究方向	Oncology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000584419500001
资助机构	National Natural Science Foundation of China ; Natural Science Foundation of Zhejiang Province ; Talent Project of Zhejiang Association for Science and Technology ; Foundation of Zhejiang Chinese Medical University ; Startup Funds for Recruited Talents at Zhejiang Cancer Hospital
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/105085]
专题	中国科学院合肥物质科学研究院
通讯作者	Chen, Tianhui; Mao, Yingying
作者单位	1.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Zhejiang Canc Hosp, Univ Chinese Acad Sci,Canc Hosp,Dept Canc Prevent, Hangzhou, Peoples R China 2.Zhejiang Chinese Med Univ, Coll Clin Med 2, Hangzhou, Peoples R China 3.Zhejiang Chinese Med Univ, Sch Basic Med Sci, Hangzhou, Peoples R China 4.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Zhejiang Canc Hosp, Univ Chinese Acad Sci,Dept Clin Lab,Canc Hosp, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	He, Chiyu,Qian, Yu,Liu, Bin,et al. Genetically Predicted Circulating Level of C-Reactive Protein Is Not Associated With Prostate Cancer Risk[J]. FRONTIERS IN ONCOLOGY,2020,10.
APA	He, Chiyu.,Qian, Yu.,Liu, Bin.,Yang, Shaoxue.,Ye, Ding.,...&Mao, Yingying.(2020).Genetically Predicted Circulating Level of C-Reactive Protein Is Not Associated With Prostate Cancer Risk.FRONTIERS IN ONCOLOGY,10.
MLA	He, Chiyu,et al."Genetically Predicted Circulating Level of C-Reactive Protein Is Not Associated With Prostate Cancer Risk".FRONTIERS IN ONCOLOGY 10(2020).