Treatment of Synchronous Liver Metastases from Gastric Cancer: A Single-Center Study

doi:10.2147/CMAR.S261353

	Treatment of Synchronous Liver Metastases from Gastric Cancer: A Single-Center Study
	Yu, Pengfei; Zhang, Yanqiang; Ye, Zeyao; Chen, Xiangliu; Huang, Ling; Du, Yian; Cheng, Xiangdong
刊名	CANCER MANAGEMENT AND RESEARCH
	2020
卷号	12
关键词	gastric neoplasm liver metastasis surgical resection chemotherapy prognosis
ISSN号	1179-1322
DOI	10.2147/CMAR.S261353
通讯作者	Cheng, Xiangdong(abdsurg@163.com)
英文摘要	Objective: The therapeutic effects of surgical resection in gastric cancer with liver metastasis remain largely unclear. We sought to examine surgical resection combined with chemotherapy for survival benefit in cases of synchronous liver metastases from gastric cancer (LMGC), and to identify factors affecting patient prognosis. Methods: Patients diagnosed with synchronous LMGC between January 2010 and December 2015 were enrolled in this study. The effects of gastrectomy and metastasectomy combined with chemotherapy (surgical resection group) and palliative chemotherapy (palliative chemotherapy group) on survival were comparatively assessed. Results: Of the 132 included cases, 57 (43.2%) and 75 (56.8%) were treated with surgical resection/chemotherapy and palliative chemotherapy, respectively. Overall survival (OS) was markedly prolonged in the surgical resection group compared with the palliative chemotherapy group (33.6 vs 12.4 months, P<0.001). In patients who underwent surgical resection, RO resection resulted in prolonged OS in comparison with the non-RO resection subgroup (45.1 vs 13.5 months, P<0.001). Surgical resection (hazard ratio [HR]=0.453; 95% confidence interval [CI] 0.276-0.813; P=0.009) and solitary liver metastasis (HR=0.540; 95% CI 0.-315-0.796; P =0.043) were independent predictors of OS. Conclusion: Patients with synchronous LMGC might benefit from radical surgical resection combined with appropriate chemotherapy. Additional well-designed prospective studies are required to verify the above findings.
资助项目	Natural Science Foundation of Zhejiang Province of China[LY18H160032] ; Medical Health Science and Technology Project of Zhejiang Provincial Health Commission[2020KY471]
WOS关键词	SURGICAL RESECTION ; HEPATIC RESECTION ; SURVIVAL ; ADENOCARCINOMA ; CHEMOTHERAPY ; HEPATECTOMY ; GASTRECTOMY ; MULTIPLE
WOS研究方向	Oncology
语种	英语
出版者	DOVE MEDICAL PRESS LTD
WOS记录号	WOS:000577375800008
资助机构	Natural Science Foundation of Zhejiang Province of China ; Medical Health Science and Technology Project of Zhejiang Provincial Health Commission
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/104684]
专题	中国科学院合肥物质科学研究院
通讯作者	Cheng, Xiangdong
作者单位	Chinese Acad Sci, Canc Hosp, Univ Chinese Acad Sci,Dept Gastr Surg, Zhejiang Canc Hosp,Inst Canc Res & Basic Med Sci, Hangzhou 310022, Peoples R China
推荐引用方式 GB/T 7714	Yu, Pengfei,Zhang, Yanqiang,Ye, Zeyao,et al. Treatment of Synchronous Liver Metastases from Gastric Cancer: A Single-Center Study[J]. CANCER MANAGEMENT AND RESEARCH,2020,12.
APA	Yu, Pengfei.,Zhang, Yanqiang.,Ye, Zeyao.,Chen, Xiangliu.,Huang, Ling.,...&Cheng, Xiangdong.(2020).Treatment of Synchronous Liver Metastases from Gastric Cancer: A Single-Center Study.CANCER MANAGEMENT AND RESEARCH,12.
MLA	Yu, Pengfei,et al."Treatment of Synchronous Liver Metastases from Gastric Cancer: A Single-Center Study".CANCER MANAGEMENT AND RESEARCH 12(2020).