Experimental vascular protective shield combined with vacuum sealing drainage prevents pressure on exposed vessels and accelerates wound repair

doi:10.21037/apm-20-625

	Experimental vascular protective shield combined with vacuum sealing drainage prevents pressure on exposed vessels and accelerates wound repair
	Du, Weibin 3; He, Lihong 3; Wang, Lixiang 3; Hu, Huahui 3; Zhou, Huateng 3; Bao, Guanai 1,2; Chen, Rongliang 3; Shen, Fuxiang 3; Quan, Renfu 3
刊名	ANNALS OF PALLIATIVE MEDICINE
	2020-09-01
卷号	9
关键词	Vascular protective shield vacuum sealing drainage (VSD) exposed vessels early vascularization wound repair
ISSN号	2224-5820
DOI	10.21037/apm-20-625
通讯作者	Du, Weibin(dwbbdm@163.com) ; Quan, Renfu(quanrenfu@126.com)
英文摘要	Background: The sustained negative pressure created by vacuum sealing drainage (VSD) on exposed vascular wounds can result in blood vessel compression, embolism, or necrosis. 'I'he objective of this research \V a s to explore the ability of an experimental vascular protective shield combined with VSD to protect exposed vessels of the lower limbs and accelerate wound repair. Methods: (I) The vascular protective shield was prepared; (II) the material was subjected to acute toxicity and hemolysis tests; (III) and 30 New Zealand rabbits were divided into three groups: the control, VSD-only, and combined shield-VSD groups (with ten rabbits in each group). The wotmd-healing rate, myocardial function, wound histopathology; expression of angiogenesis markers, and exposed vascular compression of these three groups were compared on day 7. Results: (I) The internal structure of the material was smooth; and (II) no toxicity or death was observed in mice of any group. 'I'he hemolysis rate in the combined shield-VSD group was very low. (Ill) The combined shield -VS') group showed a higher wound -healing rate, and higher levels of cluster of differentiation 31 (CD31), vascular endothelial growth factor (VEGF), and platelet -derived growth factor (PDGF), than the other groups (P<0.05), along with a better tissue healing rate. (IV) Left ventricular pressure fluctuations in the combined shield-VSD group were smaller than those in the VSD-only group (P<0.05). (V) Blood vessels in the control and combined shield-VSD group were not damaged, but were damaged in the VSD-only group. Conclusions: The experimental vascular protective shield exhibited exceptional biosafety. The combination of this shield with VSD reduces influences on systolic and diastolic capacities of myocardium and avoids multiple compressions of exposed vessels, thus contributing to early vascularization of wounds arid wound repair.
资助项目	National Natural Science Foundation of China[81904053] ; Plan Guide Project of Hangzhou Technology Department[20171226Y93] ; Plan Guide Project of Hangzhou Technology Department[20171226Y96] ; Plan Project of Hangzhou Health Science and Technology Department[2018B030] ; Great Technology Capture Project of Hangzhou Xiaoshan District[2017208] ; Great Technology Capture Project of Hangzhou Xiaoshan District[2017214]
WOS关键词	DIABETIC FOOT ULCERS ; THERAPY ; SKIN ; EXTREMITY
WOS研究方向	Health Care Sciences & Services
语种	英语
出版者	AME PUBL CO
WOS记录号	WOS:000576670500071
资助机构	National Natural Science Foundation of China ; Plan Guide Project of Hangzhou Technology Department ; Plan Project of Hangzhou Health Science and Technology Department ; Great Technology Capture Project of Hangzhou Xiaoshan District
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/104482]
专题	中国科学院合肥物质科学研究院
通讯作者	Du, Weibin; Quan, Renfu
作者单位	1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Rehabil, Hangzhou, Peoples R China 2.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou, Peoples R China 3.Zhejiang Chinese Med Univ, Jiangnan Hosp, Res Inst Orthoped, Hangzhou 312001, Peoples R China
推荐引用方式 GB/T 7714	Du, Weibin,He, Lihong,Wang, Lixiang,et al. Experimental vascular protective shield combined with vacuum sealing drainage prevents pressure on exposed vessels and accelerates wound repair[J]. ANNALS OF PALLIATIVE MEDICINE,2020,9.
APA	Du, Weibin.,He, Lihong.,Wang, Lixiang.,Hu, Huahui.,Zhou, Huateng.,...&Quan, Renfu.(2020).Experimental vascular protective shield combined with vacuum sealing drainage prevents pressure on exposed vessels and accelerates wound repair.ANNALS OF PALLIATIVE MEDICINE,9.
MLA	Du, Weibin,et al."Experimental vascular protective shield combined with vacuum sealing drainage prevents pressure on exposed vessels and accelerates wound repair".ANNALS OF PALLIATIVE MEDICINE 9(2020).