Synthesis of urchin-like nickel nanoparticles with enhanced rotating magnetic field-induced cell necrosis and tumor inhibition

doi:10.1016/j.cej.2020.125823

	Synthesis of urchin-like nickel nanoparticles with enhanced rotating magnetic field-induced cell necrosis and tumor inhibition
	Qian, Yong 3,4; Wang, Dongmei 4; Tian, Xiaofei 4; Liu, Hongji 4; Wang, Xingyu 4; Li, Hai 2; Chen, Qianwang 4,5; Zhang, Xin 1,3,4; Wang, Hui 1,4
刊名	CHEMICAL ENGINEERING JOURNAL
	2020-11-15
卷号	400
关键词	Ni nanoparticles Urchin-like structure Rotating magnetic field Cell necrosis Tumor inhibition
ISSN号	1385-8947
DOI	10.1016/j.cej.2020.125823
通讯作者	Zhang, Xin(xinzhang@hmfl.ac.cn) ; Wang, Hui(hw39@hmfl.ac.cn)
英文摘要	Magnetic nanoparticles (MNPs)-induced cell necrosis under rotating magnetic field (RMF) has attracted a great deal of attention in recent years. However, the smooth structure of MNPs largely limits their necrosis efficiency. In this study, we aimed to synthesize novel urchin-like nickel nanoparticles (UNNPs) and evaluate their high efficiency in cell necrosis and tumor inhibition under a low-frequency RMF. The unique UNNPs were prepared via a one-step solvothermal process under an external magnetic field of 0.6 T. The as-synthesized UNNPs exhibited a size distribution from 350 to 700 nm with a peak of 450 nm and ferromagnetic behavior with a magnetization saturation of 49.88 emu/g. The in vitro results showed that the as-prepared UNNPs induced much higher rate of necrotic cell death than sphere-like nickel nanoparticles under the same RMF. Both in vitro and in vivo testing revealed that the UNNPs possessed nontoxic properties. Furthermore, the UNNPs showed obvious suppression against tumor cell growth in a mouse model of malignant breast cancer under the induction of low-frequency RMF.
资助项目	start-up fund of Chinese Academy of Sciences[1600000012] ; Collaborative Innovation Program of Hefei Science Center of Chinese Academy of Sciences[2019HSC-CIP012] ; National Natural Science Foundation (NSFC)[21271163] ; Anhui Province Key Laboratory of Medical Physics and Technology[LMPT201701] ; CASHIPS Director's Fund[YZJJ201704] ; High Magnetic Field Laboratory of Anhui Province
WOS关键词	ONE-POT SYNTHESIS ; DRUG-DELIVERY ; CANCER-CELLS ; HYDROXYAPATITE NANOSTRUCTURES ; MECHANICAL DESTRUCTION ; REMOTE-CONTROL ; NANOCOMPOSITE ; NANOCARRIER ; PARTICLES ; NANOWIRES
WOS研究方向	Engineering
语种	英语
出版者	ELSEVIER SCIENCE SA
WOS记录号	WOS:000569321000003
资助机构	start-up fund of Chinese Academy of Sciences ; Collaborative Innovation Program of Hefei Science Center of Chinese Academy of Sciences ; National Natural Science Foundation (NSFC) ; Anhui Province Key Laboratory of Medical Physics and Technology ; CASHIPS Director's Fund ; High Magnetic Field Laboratory of Anhui Province
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/104087]
专题	中国科学院合肥物质科学研究院
通讯作者	Zhang, Xin; Wang, Hui
作者单位	1.Chinese Acad Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China 2.Chinese Acad Sci, Ctr Med & Phys & Technol, Hefei Inst Phys Sci, Hefei 230031, Anhui, Peoples R China 3.Anhui Univ, Inst Phys Sci, Hefei 230601, Anhui, Peoples R China 4.Chinese Acad Sci, Hefei Inst Phys Sci, Anhui Key Lab Condensed Matter Phys Extreme Condi, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China 5.Univ Sci & Technol China, Dept Mat Sci & Engn, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Qian, Yong,Wang, Dongmei,Tian, Xiaofei,et al. Synthesis of urchin-like nickel nanoparticles with enhanced rotating magnetic field-induced cell necrosis and tumor inhibition[J]. CHEMICAL ENGINEERING JOURNAL,2020,400.
APA	Qian, Yong.,Wang, Dongmei.,Tian, Xiaofei.,Liu, Hongji.,Wang, Xingyu.,...&Wang, Hui.(2020).Synthesis of urchin-like nickel nanoparticles with enhanced rotating magnetic field-induced cell necrosis and tumor inhibition.CHEMICAL ENGINEERING JOURNAL,400.
MLA	Qian, Yong,et al."Synthesis of urchin-like nickel nanoparticles with enhanced rotating magnetic field-induced cell necrosis and tumor inhibition".CHEMICAL ENGINEERING JOURNAL 400(2020).