Laser ablation in liquids for the assembly of Se@Au chain-oligomers with long-term stability for photothermal inhibition of tumor cells

doi:10.1016/j.jcis.2020.01.098

	Laser ablation in liquids for the assembly of Se@Au chain-oligomers with long-term stability for photothermal inhibition of tumor cells
	Cai, Yunyu 2,3; Zhang, Yajun 1,4; Ji, Sihan 2,3; Ye, Yixing 2,3; Wu, Shouliang 2,3; Liu, Jun 2,3; Chen, Shaopeng 4; Liang, Changhao 1,2,3
刊名	JOURNAL OF COLLOID AND INTERFACE SCIENCE
	2020-04-15
卷号	566
关键词	Au nanoparticle Se nanoparticle Chain-oligomer Laser ablation Green synthesis Photothermal therapy Directional assembly Bipolar interaction Long-term stability High photothermal transduction efficiency
ISSN号	0021-9797
DOI	10.1016/j.jcis.2020.01.098
通讯作者	Cai, Yunyu(yycai@issp.ac.cn) ; Chen, Shaopeng(spchen035@ipp.ac.cn) ; Liang, Changhao(chliang@issp.ac.cn)
英文摘要	For the potential use of Au nanoparticles (NPs) in photothermal therapy, it is important and effective to achieve the uniaxial assembly of Au NPs to allow enhanced absorption in the near infrared (NIR) region. Herein, we first presented the construction of amorphous selenium encapsulated gold (Se@Au) chainoligomers by successive laser ablation of Au and Se targets in sodium chloride solution without other toxic precursors, stabilizers, or templating molecules. Se@Au chain-oligomers showed evidently enhanced NIR absorption and excellent photothermal transduction efficiency (i), which was higher than 47% at 808 nm. After being stored for I year, the Se@Au colloids still exhibited outstanding photothermal performance. The cytotoxicity assay demonstrated that there is negligible toxicity of Se@Au chain-oligomers in cells, but cell viability declined to only 1% in phototherapeutic experiments that were implemented in vitro. In intracellular Reactive Oxygen Species (ROS) generation measurements, Se@Au chain-oligomers could trigger a 35.9% increment of ROS upon laser irradiation. The possible synergetic effects between the anticancer function of Se and photothermal behaviors of Se@Au intended to increase ROS level in cells. Therefore, such designed Se@Au chain-oligomers of high stability exhibit promising potential for their use as in vivo photothermal therapeutic agents. (C) 2020 Elsevier Inc. All rights reserved.
资助项目	Instrument Developing Project of the Chinese Academy of Sciences[YZ201627] ; National Natural Science Foundation of China (NSFC)[51571186] ; National Natural Science Foundation of China (NSFC)[11674321] ; National Natural Science Foundation of China (NSFC)[51801205]
WOS关键词	SELENIUM NANOPARTICLES ; OPTICAL-PROPERTIES ; GOLD NANORODS ; ABSORPTION ; TRANSITION ; APOPTOSIS ; SURFACES ; SPECTRA ; SOLVENT ; LIGHT
WOS研究方向	Chemistry
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000521653900029
资助机构	Instrument Developing Project of the Chinese Academy of Sciences ; National Natural Science Foundation of China (NSFC)
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/103573]
专题	中国科学院合肥物质科学研究院
通讯作者	Cai, Yunyu; Chen, Shaopeng; Liang, Changhao
作者单位	1.Univ Sci & Technol China, Dept Mat Sci & Engn, Hefei 230026, Peoples R China 2.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Solid State Phys, Key Lab Mat Phys, Hefei 230031, Anhui, Peoples R China 3.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Solid State Phys, Anhui Key Lab Nanomat & Nanotechnol, Hefei 230031, Anhui, Peoples R China 4.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Cai, Yunyu,Zhang, Yajun,Ji, Sihan,et al. Laser ablation in liquids for the assembly of Se@Au chain-oligomers with long-term stability for photothermal inhibition of tumor cells[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE,2020,566.
APA	Cai, Yunyu.,Zhang, Yajun.,Ji, Sihan.,Ye, Yixing.,Wu, Shouliang.,...&Liang, Changhao.(2020).Laser ablation in liquids for the assembly of Se@Au chain-oligomers with long-term stability for photothermal inhibition of tumor cells.JOURNAL OF COLLOID AND INTERFACE SCIENCE,566.
MLA	Cai, Yunyu,et al."Laser ablation in liquids for the assembly of Se@Au chain-oligomers with long-term stability for photothermal inhibition of tumor cells".JOURNAL OF COLLOID AND INTERFACE SCIENCE 566(2020).