Strong static magnetic field delayed the early development of zebrafish

doi:10.1098/rsob.190137

	Strong static magnetic field delayed the early development of zebrafish
	Ge, Shuchao 2; Li, Jingchen 1; Huang, Dengfeng 2; Cai, Yuan 2; Fang, Jun 3; Jiang, Hongyuan 1; Hu, Bing 2
刊名	OPEN BIOLOGY
	2019-10-01
卷号	9
关键词	zebrafish early development strong static magnetic field microtubules spindle mitosis
DOI	10.1098/rsob.190137
通讯作者	Jiang, Hongyuan(jianghy@ustc.edu.cn) ; Hu, Bing(bhu@ustc.edu.cn)
英文摘要	One of the major topics in magnetobiology is the biological effects of strong static magnetic field (SMF) on living organisms. However, there has been a paucity of the comprehensive study of the long-term effects of strong SMF on an animal's development. Here, we explored this question with zebrafish, an excellent model organism for developmental study. In our research, zebrafish eggs, just after fertilization, were exposed to a 9.0 T SMF for 24 h, the critical period of post-fertilization development from cleavage to segmentation. The effects of strong SMF exposure on the following developmental progress of zebrafish were studied until 6 days post-fertilization (dpf). Results showed that 9.0 T SMF exposure did not influence the survival or the general developmental scenario of zebrafish embryos. However, it slowed down the developmental pace of the whole animal, and the late developers would catch up with their control peers after the SMF was removed. We proposed a mechanical model and deduced that the development delaying effect was caused by the interference of SMF in microtubule and spindle positioning during mitosis, especially in early cleavages. Our research data provide insights into how strong SMF influences the developing organisms through basic physical interactions with intracellular macromolecules.
资助项目	Chinese MOST[2019YFA0405600] ; NSFC[U1332136] ; NSFC[81790643]
WOS关键词	EMBRYONIC-DEVELOPMENT ; XENOPUS-LAEVIS ; UPPER LIMIT ; SPINDLE ; MICROTUBULES ; ORIENTATION ; MECHANISMS ; ACTIN ; FORCE ; CELLS
WOS研究方向	Biochemistry & Molecular Biology
语种	英语
出版者	ROYAL SOC
WOS记录号	WOS:000521587300004
资助机构	Chinese MOST ; NSFC
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/103501]
专题	中国科学院合肥物质科学研究院
通讯作者	Jiang, Hongyuan; Hu, Bing
作者单位	1.Univ Sci & Technol China, CAS Ctr Excellence Complex Syst Mech, Dept Modern Mech, Hefei Natl Lab Phys Sci Microscale,CAS Key Lab Me, Hefei 230027, Anhui, Peoples R China 2.Univ Sci & Technol China, Sch Life Sci, CAS Key Lab Brain Funct & Dis, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Anhui, Peoples R China 3.Chinese Acad Sci, High Field Magnet Lab, Anhui Prov Key Lab Condensed Matter Phys Extreme, Hefei 230031, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Ge, Shuchao,Li, Jingchen,Huang, Dengfeng,et al. Strong static magnetic field delayed the early development of zebrafish[J]. OPEN BIOLOGY,2019,9.
APA	Ge, Shuchao.,Li, Jingchen.,Huang, Dengfeng.,Cai, Yuan.,Fang, Jun.,...&Hu, Bing.(2019).Strong static magnetic field delayed the early development of zebrafish.OPEN BIOLOGY,9.
MLA	Ge, Shuchao,et al."Strong static magnetic field delayed the early development of zebrafish".OPEN BIOLOGY 9(2019).