Metformin up-regulated miR-107 expression and enhanced the inhibitory effect of miR-107 on gastric cancer growth

doi:10.21037/tcr.2020.03.25

	Metformin up-regulated miR-107 expression and enhanced the inhibitory effect of miR-107 on gastric cancer growth
	Chen, Yongyi 1,2,3; Gong, Wangang 1,2,3; Zhou, Yun 1,2,3; Fan, Runping 1,2,3; Wu, Yuchen 1,2,3; Pei, Wangwei 1,2,3; Sun, Sufang 1,2,3; Xu, Xiaohong 1,2,3; Jiang, Huifen 1,2,3
刊名	TRANSLATIONAL CANCER RESEARCH
	2020-04-01
卷号	9
关键词	Gastric cancer (GC) metformin miR-107 bioinformatics analysis survival outcomes proliferation
ISSN号	2218-676X
DOI	10.21037/tcr.2020.03.25
通讯作者	Jiang, Huifen(jianghuifentougao@163.com)
英文摘要	Gastric cancer (GC) is one of the most common malignant neoplasms and is the third leading cause of cancer-related death around the world. Metformin has been well reported to have an inhibitory effect on the growth of various cancers by regulating the expression of microRNAs (miRNAs). However, the specific miRNA(s) regulated by metformin in GC have not been identified. In this study, real-time reverse transcription polymerase chain reaction (RT-PCR) analysis in vitro indicated that miR-107 expression was up-regulated in metformin-treated SGC-7901 cells compared with untreated SGC-7901 and MGC803 cells. Amplification of miR-107 expression further reduced cell proliferation in metformin-treated GC cells. A bioinformatics analysis showed that mitogen-activated protein kinase 8 (MAPK8) was the common target of metformin and miR-107. MAPK8 expression is associated with immune cell infiltration in GC as well as overall GC patient survival. Our study demonstrates that rniR-107 enhances the anti-cancer effects of metformin in GC tissues, which offers a novel strategy for the treatment of GC.
资助项目	Medical and Health Science and Technology Project of Zhejiang Province[2015KYB060]
WOS关键词	IN-VITRO ; SENSITIVITY ; MICRORNAS ; CELLS ; DRUG
WOS研究方向	Oncology
语种	英语
出版者	AME PUBL CO
WOS记录号	WOS:000530914200079
资助机构	Medical and Health Science and Technology Project of Zhejiang Province
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/103279]
专题	中国科学院合肥物质科学研究院
通讯作者	Jiang, Huifen
作者单位	1.Chinese Acad Sci, Inst Canc Res & Basic Med Sci, Hangzhou 310022, Peoples R China 2.Univ Chinese Acad Sci, Canc Hosp, Dept Clin Lab, Hangzhou 310022, Peoples R China 3.Zhejiang Canc Hosp, Dept Clin Lab, 1 East Banshan Rd, Hangzhou 310022, Peoples R China
推荐引用方式 GB/T 7714	Chen, Yongyi,Gong, Wangang,Zhou, Yun,et al. Metformin up-regulated miR-107 expression and enhanced the inhibitory effect of miR-107 on gastric cancer growth[J]. TRANSLATIONAL CANCER RESEARCH,2020,9.
APA	Chen, Yongyi.,Gong, Wangang.,Zhou, Yun.,Fan, Runping.,Wu, Yuchen.,...&Jiang, Huifen.(2020).Metformin up-regulated miR-107 expression and enhanced the inhibitory effect of miR-107 on gastric cancer growth.TRANSLATIONAL CANCER RESEARCH,9.
MLA	Chen, Yongyi,et al."Metformin up-regulated miR-107 expression and enhanced the inhibitory effect of miR-107 on gastric cancer growth".TRANSLATIONAL CANCER RESEARCH 9(2020).