Genetically predicted levels of circulating cytokines and prostate cancer risk: A Mendelian randomization study

doi:10.1002/ijc.33221

	Genetically predicted levels of circulating cytokines and prostate cancer risk: A Mendelian randomization study
	Sun, Xiaohui 2; Ye, Ding 2; Du, Lingbin 3,4,5; Qian, Yu 2; Jiang, Xia 1,6; Mao, Yingying 2
刊名	INTERNATIONAL JOURNAL OF CANCER
	2020-08-12
关键词	cytokines inflammation Mendelian randomization monocyte chemotactic protein-1 prostate cancer
ISSN号	0020-7136
DOI	10.1002/ijc.33221
通讯作者	Jiang, Xia(xia.jiang@ki.se) ; Mao, Yingying(myy@zcmu.edu.cn)
英文摘要	Inflammation is considered to play a pivotal role in the pathogenesis of cancer, and observational studies have reported a relationship between circulating inflammation markers and the risk of prostate cancer. Using summary data of >140 000 individuals, two-sample Mendelian randomization (MR) analyses were performed to evaluate whether circulating levels of 27 cytokines and growth factors have a causal effect on the risk of developing prostate cancer. Genetically predicted elevated levels of monocyte chemotactic protein-1 (MCP-1) were associated with an increased risk of prostate cancer (odds ratio (OR) per 1 SD increase = 1.06, 95% confidence interval (CI): 1.04-1.09) at Bonferroni-adjusted level of significance (P < 1.85 x 10(-3)). Results were stable across sensitivity analyses, and there was no evidence of directional pleiotropy. Under MR assumptions, our findings suggested a risk-increasing effect of circulating MCP-1 levels on prostate cancer. Whether targeting MCP-1 or its downstream effectors are useful in reducing prostate cancer incidence needs further investigation.
资助项目	Foundation of Zhejiang Chinese Medical University[2020ZR09] ; Foundation of Zhejiang Chinese Medical University[KC201905] ; National Natural Science Foundation of China[81602917] ; National Natural Science Foundation of China[81973663] ; Natural Science Foundation of Zhejiang Province[LQ20H260008] ; Talent Project of Zhejiang Association for Science and Technology[2018YCGC003]
WOS关键词	HEPATOCYTE GROWTH-FACTOR ; PROTEIN-1 MCP-1 ; CHEMOKINE ; VARIANTS ; POLYMORPHISMS ; EXPRESSION ; MIGRATION ; EPIDEMIOLOGY ; INFLAMMATION ; PROGRESSION
WOS研究方向	Oncology
语种	英语
出版者	WILEY
WOS记录号	WOS:000558419000001
资助机构	Foundation of Zhejiang Chinese Medical University ; National Natural Science Foundation of China ; Natural Science Foundation of Zhejiang Province ; Talent Project of Zhejiang Association for Science and Technology
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/102909]
专题	中国科学院合肥物质科学研究院
通讯作者	Jiang, Xia; Mao, Yingying
作者单位	1.Karolinska Inst, Ctr Mol Med, S-17177 Stockholm, Sweden 2.Zhejiang Chinese Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hangzhou 310053, Zhejiang, Peoples R China 3.Chinese Acad Sci, Inst Canc & Basic Med ICBM, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Canc Hosp, Dept Canc Prevent, Beijing, Peoples R China 5.Zhejiang Canc Hosp, Dept Canc Prevent, Hangzhou, Zhejiang, Peoples R China 6.Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA
推荐引用方式 GB/T 7714	Sun, Xiaohui,Ye, Ding,Du, Lingbin,et al. Genetically predicted levels of circulating cytokines and prostate cancer risk: A Mendelian randomization study[J]. INTERNATIONAL JOURNAL OF CANCER,2020.
APA	Sun, Xiaohui,Ye, Ding,Du, Lingbin,Qian, Yu,Jiang, Xia,&Mao, Yingying.(2020).Genetically predicted levels of circulating cytokines and prostate cancer risk: A Mendelian randomization study.INTERNATIONAL JOURNAL OF CANCER.
MLA	Sun, Xiaohui,et al."Genetically predicted levels of circulating cytokines and prostate cancer risk: A Mendelian randomization study".INTERNATIONAL JOURNAL OF CANCER (2020).