Functional terpyridyl iron complexes forin vivophotoacoustic imaging

doi:10.1039/d0qi00058b

	Functional terpyridyl iron complexes forin vivophotoacoustic imaging
	Xiang, Pan 4,5; Shen, Yu 3; Shen, Jie 3; Feng, Zhihui 3; Sun, Min 5; Zhang, Qiong 3; Li, Shengli 3; Li, Dandan 3; Zhang, Guilong 1; Wu, Zhengyan 1
刊名	INORGANIC CHEMISTRY FRONTIERS
	2020-07-28
卷号	7
ISSN号	2052-1553
DOI	10.1039/d0qi00058b
通讯作者	Sun, Min(sunmin@ahu.edu.cn) ; Tian, Xiaohe(xiaohe.t@ahu.edu.cn)
英文摘要	Photoacoustic (PA) imaging has received extensive attention in the recent decade due to its ultra-high resolution in deep tissue penetration, whereas functional PA probes with tunable molecular structure at a low cost level remain a significant challenge. Herein, we have rationally designed three triple-pyridyl iron complexes with different water solubilities. These complexes show a higher photothermal conversion efficiency due to their rapid excited-state deactivation, making them suitable as PA probes. Notably, the photothermal conversion efficiency of one complex namedS-Fecould reach as high as 29.6%. In addition,S-Fehas excellent solubility and biocompatibility, which enable PA imagingin vivo. Significantly, further pharmacokinetics evaluation demonstrated that this complex showed minimal invasiveness for live animals and displayed a relatively fast metabolism rate. This study using inexpensive iron complexes as PA agents upgraded the toolbox for PA imaging and correlated multi-modal imaging applications.
资助项目	National Nature Science Foundation of China[21602003] ; National Nature Science Foundation of China[21871003] ; National Nature Science Foundation of China[51432001] ; National Nature Science Foundation of China[21701160]
WOS关键词	BIOCOMPATIBILITY
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000553934700002
资助机构	National Nature Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/70469]
专题	中国科学院合肥物质科学研究院
通讯作者	Sun, Min; Tian, Xiaohe
作者单位	1.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Peoples R China 2.Chinese Acad Sci, CAS Ctr Excellence Nanosci, Inst Intelligent Machines, Hefei 230000, Peoples R China 3.Anhui Univ, Dept Chem, Anhui Prov Key Lab Chem Inorgan Organ Hybrid Func, Hefei 230601, Peoples R China 4.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230601, Peoples R China 5.Anhui Univ, Sch Life Sci, Hefei 230601, Peoples R China
推荐引用方式 GB/T 7714	Xiang, Pan,Shen, Yu,Shen, Jie,et al. Functional terpyridyl iron complexes forin vivophotoacoustic imaging[J]. INORGANIC CHEMISTRY FRONTIERS,2020,7.
APA	Xiang, Pan.,Shen, Yu.,Shen, Jie.,Feng, Zhihui.,Sun, Min.,...&Tian, Xiaohe.(2020).Functional terpyridyl iron complexes forin vivophotoacoustic imaging.INORGANIC CHEMISTRY FRONTIERS,7.
MLA	Xiang, Pan,et al."Functional terpyridyl iron complexes forin vivophotoacoustic imaging".INORGANIC CHEMISTRY FRONTIERS 7(2020).