Cohort Study on Prognosis of Patients with Metastatic Colorectal Cancer Treated with Integrated Chinese and Western Medicine

	Cohort Study on Prognosis of Patients with Metastatic Colorectal Cancer Treated with Integrated Chinese and Western Medicine
刊名	CHINESE JOURNAL OF INTEGRATIVE MEDICINE
	2018
卷号	24
关键词	cohort study metastatic colorectal cancer integrative medicine
ISSN号	1672-0415
其他题名	Cohort Study on Prognosis of Patients with Metastatic Colorectal Cancer Treated with Integrated Chinese and Western Medicine
英文摘要	Objective: To investigate the efficacy of integrated Chinese and Western medicine (IM) in the treatment of metastatic colorectal cancer (mCRC) in a cohort study. Methods: The survival outcome of patients receiving IM was compared with that of patients receiving Western medicine alone. The study design was adopted with "continuous administration of Chinese medicine for >= 3 months" as the exposure factor. Patients who met this exposure factor were assigned to the IM cohort (Group A, 110 patients). Patients who did not meet this exposure factor were assigned to the Western medicine cohort (Group B, 225 patients). The overall survival (OS), progression-free survival (PFS), and 1st year, 2nd year, and 3rd year survival in the two cohorts were compared. Results: The median OS in Group A and B were 18 months 95% confidence interval (CI) 15-21 and 16 months (95% CI 14-18), respectively, and the median PFS in Group A and B were 6 months (95% CI 4-7) and 5 months (95% CI 4-6), respectively. No statistically significant differences were observed between the groups (P=0.186, P=0.223). Group A demonstrated significantly longer OS and PFS than Group B in the following subgroups: female patients, patients with lesions in the right half of the colon, and those who received first-line treatment (P<0.05). In the subgroup of elderly patients (age>65 years), the OS in Group A was longer than that in Group B (P<0.05). Conclusion: IM could prolong the survival of patients with mCRC.
资助项目	[National Natural Science Foundation of China] ; [Beijing Health Development Research Project] ; [Project of the Chinese Academy of Traditional Chinese Medicine]
语种	英语
CSCD记录号	CSCD:6282435
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/63402]
专题	中国科学院合肥物质科学研究院
推荐引用方式 GB/T 7714	. Cohort Study on Prognosis of Patients with Metastatic Colorectal Cancer Treated with Integrated Chinese and Western Medicine[J]. CHINESE JOURNAL OF INTEGRATIVE MEDICINE,2018,24.
APA	(2018).Cohort Study on Prognosis of Patients with Metastatic Colorectal Cancer Treated with Integrated Chinese and Western Medicine.CHINESE JOURNAL OF INTEGRATIVE MEDICINE,24.
MLA	"Cohort Study on Prognosis of Patients with Metastatic Colorectal Cancer Treated with Integrated Chinese and Western Medicine".CHINESE JOURNAL OF INTEGRATIVE MEDICINE 24(2018).