Influenza Virus Assembly and Budding in Lipid Rafts

	Influenza Virus Assembly and Budding in Lipid Rafts
刊名	PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
	2015
卷号	42
关键词	M2 PROTEIN CYTOPLASMIC TAIL MATRIX PROTEIN LINE TENSION HEMAGGLUTININ MEMBRANE NEURAMINIDASE CELL ORGANIZATION ESCAPE influenza virus lipid rafts virus assembly membrane budding membrane scission protein M2
ISSN号	1000-3282
其他题名	Influenza Virus Assembly and Budding in Lipid Rafts
英文摘要	Influenza A virus causes annual epidemics, and occasional pandemics that bring a significant global health threat. Influenza virus, which belongs to the Orthomyxoviridae family, is an enveloped virus that contains a segmented and negative-sense RNA genome. The assembly and budding of progeny influenza is a complicated and multi-step process involving many viral factors. Influenza budding occurs in lipid raft domains of cells membrane. Firstly, two viral glycoproteins HA and NA, concentrate in lipid rafts to initiate the budding process by causing membrane enlargement and curvature. Secondly Matrix protein 1 (MI), which forms the inner virion matrix, is then recruited to the budding site followed by the incorporation of viral VPNPs and M2 proteins. In the later stages of budding, M2 is concentrated to the bottom of the budding virion at the lipid rafts boundary, resulting in viral scission and virion release.
资助项目	[National Natural Science Foundation of China]
语种	英语
CSCD记录号	CSCD:5446543
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/49366]
专题	中国科学院合肥物质科学研究院
推荐引用方式 GB/T 7714	. Influenza Virus Assembly and Budding in Lipid Rafts[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2015,42.
APA	(2015).Influenza Virus Assembly and Budding in Lipid Rafts.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,42.
MLA	"Influenza Virus Assembly and Budding in Lipid Rafts".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 42(2015).