Insights into Nanomedicine for Immunotherapeutics in Squamous Cell Carcinoma of the head and neck

doi:10.7150/ijbs.47068

	Insights into Nanomedicine for Immunotherapeutics in Squamous Cell Carcinoma of the head and neck
	Xu, Qiang 2,3; Fang, Meiyu 3,4; Zhu, Jing 3,5; Dong, Haoru 6; Cao, Jun 3,4; Yan, Lin 7; Leonard, Fransisca 8; Oppel, Felix 9; Sudhoff, Holger 9; Kaufmann, Andreas M.10,11,12,13
刊名	INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
	2020
卷号	16
关键词	nanotherapeutics drug delivery cancer immunotherapy nanovaccine head and neck squamous cell carcinoma human papillomavirus
ISSN号	1449-2288
DOI	10.7150/ijbs.47068
通讯作者	Qian, Xu(qian_michelle2014@163.com)
英文摘要	Immunotherapies such as immune checkpoint blockade benefit only a portion of patients with head and neck squamous cell carcinoma. The multidisciplinary field of nanomedicine is emerging as a promising strategy to achieve maximal anti-tumor effect in cancer immunotherapy and to turn non-responders into responders. Various methods have been developed to deliver therapeutic agents that can overcome bio-barriers, improve therapeutic delivery into the tumor and lymphoid tissues and reduce adverse effects in normal tissues. Additional modification strategies also have been employed to improve targeting and boost cytotoxic T cell-based immune responses. Here, we review the state-of-the-art use of nanotechnologies in the laboratory, in advanced preclinical phases as well as those running through clinical trials assessing their advantages and challenges.
资助项目	National Natural Science Foundation of China[81702091] ; Medical and the Health Science Project of Zhejiang Province[2019KY327] ; Guangji Talents Foundation Award (E) of Zhejiang Cancer Hospital
WOS关键词	NANOPARTICLE VACCINE ; NAB-PACLITAXEL ; OPEN-LABEL ; CANCER ; DELIVERY ; EFFICACY ; PEPTIDE ; POTENT ; DNA ; CISPLATIN
WOS研究方向	Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
语种	英语
出版者	IVYSPRING INT PUBL
WOS记录号	WOS:000555111400003
资助机构	National Natural Science Foundation of China ; Medical and the Health Science Project of Zhejiang Province ; Guangji Talents Foundation Award (E) of Zhejiang Cancer Hospital
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/45143]
专题	中国科学院合肥物质科学研究院
通讯作者	Qian, Xu
作者单位	1.Charite Univ Med Berlin, Dept Otolaryngol Head & Neck Surg, Berlin, Germany 2.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Hangzhou, Peoples R China 3.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou, Peoples R China 4.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Key Lab Head & Neck Canc Translat Res Zhejiang Pr, Hangzhou, Peoples R China 5.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Clin Lab, Hangzhou, Peoples R China 6.Wenzhou Med Univ, Sch Clin Med 1, Wenzhou, Peoples R China 7.Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China 8.Houston Methodist Res Inst, Dept Nanomed, Houston, TX USA 9.Klinikum Bielefeld, Dept Otolaryngol Head & Neck Surg, Bielefeld, Germany 10.Charite Univ Med Berlin, Clin Gynecol, Berlin, Germany
推荐引用方式 GB/T 7714	Xu, Qiang,Fang, Meiyu,Zhu, Jing,et al. Insights into Nanomedicine for Immunotherapeutics in Squamous Cell Carcinoma of the head and neck[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2020,16.
APA	Xu, Qiang.,Fang, Meiyu.,Zhu, Jing.,Dong, Haoru.,Cao, Jun.,...&Qian, Xu.(2020).Insights into Nanomedicine for Immunotherapeutics in Squamous Cell Carcinoma of the head and neck.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,16.
MLA	Xu, Qiang,et al."Insights into Nanomedicine for Immunotherapeutics in Squamous Cell Carcinoma of the head and neck".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 16(2020).