Insight into the efficiency of oxygen introduced photodynamic therapy (PDT) and deep PDT against cancers with various assembled nanocarriers

doi:10.1002/wnan.1583

	Insight into the efficiency of oxygen introduced photodynamic therapy (PDT) and deep PDT against cancers with various assembled nanocarriers
	Zhao, Jie 3; Duan, Li 4; Wang, Anhe 1; Fei, Jinbo 3; Li, Junbai 2,3
刊名	WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
	2019-09-30
页码	20
关键词	Nanocarriers Photodynamic therapy (PDT) Oxygen introduction Deep PDT Cancers
ISSN号	1939-5116
DOI	10.1002/wnan.1583
英文摘要	Photodynamic therapy (PDT) has been used in the treatment of cancers and other benign diseases for several years in clinic. However, the hypoxia of tumors and the penetration limitation of excitation light to tissues can dramatically reduce the efficacy of PDT to cancers. To overcome these drawbacks, various assembled nanocarriers such as nanoparticles, nanocapsules, nanocrystals, and so on were introduced. The assembled nanocarriers have the ability of loading photosensitizers, delivering O-2 into tumors, generating O-2 in situ in tumors, as well as turning near-infrared (NIR) light, X-rays, and chemical energy into ultraviolet or visible light. Therefore, it is easy for the nanocarriers to improve the hypoxia microenvironment or increase the treatment depth of cancers, which will improve the efficiency of PDT to some degree. In recent years, a number of investigations were focused on these subjects. We will summarize the advances of nanocarriers in PDT, especially in O-2 introduction PDT and deep PDT. The perspectives, challenges, and potential in translation of PDT will also be discussed. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Biology-Inspired Nanomaterials > Lipid-Based Structures Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease
资助项目	National Nature Science Foundation of China[21433010] ; National Nature Science Foundation of China[21872150] ; National Nature Science Foundation of China[91027045]
WOS关键词	UP-CONVERSION NANOPARTICLES ; NEAR-INFRARED LIGHT ; MESOPOROUS SILICA NANOPARTICLES ; METAL-ORGANIC FRAMEWORKS ; IN-VIVO ; HIGHLY EFFICIENT ; 2-PHOTON ABSORPTION ; INDOCYANINE GREEN ; SINGLET OXYGEN ; GOLD NANORODS
WOS研究方向	Science & Technology - Other Topics ; Research & Experimental Medicine
语种	英语
出版者	WILEY
WOS记录号	WOS:000488163600001
资助机构	National Nature Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/30866]
专题	中国科学院过程工程研究所
通讯作者	Li, Junbai
作者单位	1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Chem, BNLMS, CAS Key Lab Colloid Interface & Chem Thermodynam, Beijing 100190, Peoples R China 4.Northwest Inst Nucl Technol, Xian, Shanxi, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Jie,Duan, Li,Wang, Anhe,et al. Insight into the efficiency of oxygen introduced photodynamic therapy (PDT) and deep PDT against cancers with various assembled nanocarriers[J]. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY,2019:20.
APA	Zhao, Jie,Duan, Li,Wang, Anhe,Fei, Jinbo,&Li, Junbai.(2019).Insight into the efficiency of oxygen introduced photodynamic therapy (PDT) and deep PDT against cancers with various assembled nanocarriers.WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY,20.
MLA	Zhao, Jie,et al."Insight into the efficiency of oxygen introduced photodynamic therapy (PDT) and deep PDT against cancers with various assembled nanocarriers".WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2019):20.