DWARF 53 acts as a repressor of strigolactone signalling in rice

doi:10.1038/nature12870

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物靶标结构与功能中心

	DWARF 53 acts as a repressor of strigolactone signalling in rice
	Jiang, Liang 3,4; Liu, Xue 3,4; Xiong, Guosheng 3,4; Liu, Huihui 3,4; Chen, Fulu 3,4; Wang, Lei 3,4; Meng, Xiangbing 3,4; Liu, Guifu 3,4; Yu, Hong 3,4; Yuan, Yundong 3,4
刊名	NATURE
	2013-12-19
卷号	504 期号:7480 页码:401-+
ISSN号	0028-0836
DOI	10.1038/nature12870
文献子类	Article
英文摘要	Strigolactones (SLs) are a group of newly identified plant hormones that control plant shoot branching. SL signalling requires the hormone-dependent interaction of DWARF14 (D14), a probable candidate SL receptor, with DWARF3 (D3), an F-box component of the Skp-Cullin-F-box (SCF) E3 ubiquitin ligase complex. Here we report the characterization of a dominant SL-insensitive rice (Oryza sativa) mutant dwarf 53 (d53) and the cloning of D53, which encodes a substrate of the SCFD3 ubiquitination complex and functions as a repressor of SL signalling. Treatments with GR24, a synthetic SL analogue, cause D53 degradation via the proteasome in a manner that requires D14 and the SCFD3 ubiquitin ligase, whereas the dominant form of D53 is resistant to SL-mediated degradation. Moreover, D53 can interact with transcriptional co-repressors known as TOPLESS-RELATED PROTEINS. Our results suggest a model of SL signalling that involves SL-dependent degradation of the D53 repressor mediated by the D14-D3 complex.
资助项目	Ministry of Science and Technology of the People's Republic of China[2012AA10A301] ; National Natural Science Foundation of China[31025004] ; National Natural Science Foundation of China[90817108] ; National Natural Science Foundation of China[91217311]
WOS关键词	ORYZA-SATIVA-L ; BUD OUTGROWTH ; CO-REPRESSOR ; ARABIDOPSIS ; TOPLESS ; KARRIKIN ; ORTHOLOG ; HORMONE ; GENES ; LEAF
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000328575300044
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277333]
专题	药物靶标结构与功能中心
通讯作者	Li, Jiayang
作者单位	1.Van Andel Res Inst, Lab Struct Sci, Grand Rapids, MI 49503 USA; 2.Chinese Acad Agr Sci, China Natl Rice Res Inst, State Key Lab Rice Biol, Hangzhou 310006, Zhejiang, Peoples R China 3.Chinese Acad Sci, Inst Genet & Dev Biol, Natl Ctr Plant Gene Res Beijing, Beijing 100101, Peoples R China; 4.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Plant Genom, Beijing 100101, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Ctr Struct & Funct Drug Targets,VARI SIMM Ctr, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Jiang, Liang,Liu, Xue,Xiong, Guosheng,et al. DWARF 53 acts as a repressor of strigolactone signalling in rice[J]. NATURE,2013,504(7480):401-+.
APA	Jiang, Liang.,Liu, Xue.,Xiong, Guosheng.,Liu, Huihui.,Chen, Fulu.,...&Li, Jiayang.(2013).DWARF 53 acts as a repressor of strigolactone signalling in rice.NATURE,504(7480),401-+.
MLA	Jiang, Liang,et al."DWARF 53 acts as a repressor of strigolactone signalling in rice".NATURE 504.7480(2013):401-+.