Effects of group housing on ECG assessment in conscious cynomolgus monkeys

doi:10.1016/j.vascn.2015.05.004

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	Effects of group housing on ECG assessment in conscious cynomolgus monkeys
	Xing, Guozhen 2; Lu, Jing 2; Hu, Miaomiao 2; Wang, Shaodong 2; Zhao, Li 2; Zheng, Weijun 2; Schofield, Jason 3; Oldman, Karen 1; Adkins, Debbie 1; Yu, Hong 2
刊名	JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
	2015-09
卷号	75 页码:44-51
关键词	Electrocardiogram Group housing Heart rate Methods Moxifloxacin Non-human primate Non-invasive telemetry QT interval Safety pharmacology Single housing
ISSN号	1056-8719
DOI	10.1016/j.vascn.2015.05.004
文献子类	Article
英文摘要	Introduction: Assessing the cardiovascular safety of new chemical or biological entities is important during pre-clinical development. Electrocardiogram (ECG) assessments in non-human primate (NHP) toxicology studies are often made using non-invasive telemetry systems. We investigated whether ECG recording was feasible during group housing of NHPs, rather than the usual single housed arrangement, and whether it would impact the data collected or affect the ability to detect drug-induced changes in QTc interval. Methods: Following a period of acclimatisation to jackets, cynomolgus monkeys (3 males and 3 females) were housed in same sex groups of 3. Female monkeys were administered 4 doses of vehicle while male monkeys were administered vehicle, 15, 45, and 135 mg/kg moxifloxacin. Each dose was administered on a separate dosing day. The same dosing protocol was repeated with the animals singly housed and the results from the two phases were compared including assessment of statistical power. Results: Heart rate (HR) was significantly lower, and PR and QT intervals were significantly higher, at multiple time points when the animals were group housed compared with the singly housed phase. QRS duration and QTc interval were less affected. Moxifloxacin increased QT and QTc intervals but had no consistent effect on HR, QRS duration or PR interval under group housed or singly housed conditions. Power analysis suggested that group housing did not adversely affect the magnitude of detectable changes of ECG parameters. In general, detection of slightly smaller changes was achieved under conditions of group housing. Discussion: The current study shows group housing to be technically possible during non-invasive ECG recording, resulting in lower resting heart rates and small improvements in sensitivity of detection of drug-induced effects. Given the psychological benefits of group housing for NHPs, it is a refinement that should be considered when conducting ECG assessments in NHP toxicology studies. (C) 2015 Elsevier Inc. All rights reserved.
WOS关键词	SAFETY PHARMACOLOGY ; NONHUMAN-PRIMATES ; TOXICOLOGY ; TELEMETRY
WOS研究方向	Pharmacology & Pharmacy ; Toxicology
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000361971300007
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276407]
专题	药物安全性评价中心
通讯作者	Ren, Jin
作者单位	1.AstraZeneca R&D, Discovery Sci Stat, Macclesfield SK10 4TG, Cheshire, England 2.Chinese Acad Sci, SIMM, State Key Lab New Drug Res, CDSER, Shanghai 201203, Peoples R China; 3.AstraZeneca R&D, Dept Safety & Metab, Macclesfield SK10 4TG, Cheshire, England;
推荐引用方式 GB/T 7714	Xing, Guozhen,Lu, Jing,Hu, Miaomiao,et al. Effects of group housing on ECG assessment in conscious cynomolgus monkeys[J]. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS,2015,75:44-51.
APA	Xing, Guozhen.,Lu, Jing.,Hu, Miaomiao.,Wang, Shaodong.,Zhao, Li.,...&Skinner, Matthew.(2015).Effects of group housing on ECG assessment in conscious cynomolgus monkeys.JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS,75,44-51.
MLA	Xing, Guozhen,et al."Effects of group housing on ECG assessment in conscious cynomolgus monkeys".JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 75(2015):44-51.