Dysiherbols A-C and Dysideanone E, Cytotoxic and NF-kappa B Inhibitory Tetracyclic Meroterpenes from a Dysidea sp Marine Sponge

doi:10.1021/acs.jnatprod.5b01079

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	Dysiherbols A-C and Dysideanone E, Cytotoxic and NF-kappa B Inhibitory Tetracyclic Meroterpenes from a Dysidea sp Marine Sponge
	Jiao, Wei-Hua 1; Shi, Guo-Hua 1; Xu, Ting-Ting 1; Chen, Guo-Dong 2; Gu, Bin-Bin 1; Wang, Zhuo 1; Peng, Shuang 1,3; Wang, Shu-Ping 1; Li, Jia4 ; Han, Bing-Nan 1
刊名	JOURNAL OF NATURAL PRODUCTS
	2016-02
卷号	79 期号:2 页码:406-411
ISSN号	0163-3864
DOI	10.1021/acs.jnatprod.5b01079
文献子类	Article
英文摘要	Four new tetracyclic meroterpnes, dysiherbols A-C (1-3) and dysideanone E (4), were isolated from a Dysidea sp. marine sponge collected from the South China Sea. Their complete structures and absolute configurations were unambiguously determined by a combination of NMR spectroscopic data, ECD calculations, and single crystal X-ray diffraction analysis. Within the sesquiterpene quinol structures, dysiherbols A-C possess an intriguing 6/6/5/6-fused tetracyclic carbon skeleton. The NF-kappa B inhibitory and cytotoxic activity evaluation disclosed that dysiherbol A (1) showed potent activity with respective IC50 values of 0.49 and 0.58 mu M, which were about 10-fold and 20-fold more potent than those of dysiherbols B (2) and C (3), which feature hydroxy and ketone carbonyl groups at the C-3 position.
资助项目	National Natural Science Fund for Distinguished Young Scholars of China[81225023] ; Shanghai Rising-Star Program[14QA1402800] ; National Natural Science Fund of China[41576130] ; National Natural Science Fund of China[41428602] ; National Natural Science Fund of China[81402844] ; National Natural Science Fund of China[81373321] ; National Natural Science Fund of China[41476121] ; Fund of the Science and Technology Commission of Shanghai Municipality[14431901300] ; National High Technology Research and Development Program of China (863 Project)[2013AA092902]
WOS关键词	SESQUITERPENE QUINONES ; NATURAL-PRODUCTS ; CIRCULAR-DICHROISM ; AVARA ; AMINOQUINONES ; FRAGILIS ; GROWTH ; CANCER ; CELLS
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000371282000018
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276157]
专题	国家新药筛选中心药物安全性评价中心
通讯作者	Lin, Hou-Wen
作者单位	1.Shanghai Jiao Tong Univ, State Key Lab Oncogenes & Related Genes, Res Ctr Marine Drugs, Dept Pharm,Ren Ji Hosp,Sch Med, Shanghai 200127, Peoples R China; 2.Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China; 3.Flinders Univ S Australia, Ctr Marine Bioprod Dev, Adelaide, SA 5001, Australia; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Jiao, Wei-Hua,Shi, Guo-Hua,Xu, Ting-Ting,et al. Dysiherbols A-C and Dysideanone E, Cytotoxic and NF-kappa B Inhibitory Tetracyclic Meroterpenes from a Dysidea sp Marine Sponge[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(2):406-411.
APA	Jiao, Wei-Hua.,Shi, Guo-Hua.,Xu, Ting-Ting.,Chen, Guo-Dong.,Gu, Bin-Bin.,...&Lin, Hou-Wen.(2016).Dysiherbols A-C and Dysideanone E, Cytotoxic and NF-kappa B Inhibitory Tetracyclic Meroterpenes from a Dysidea sp Marine Sponge.JOURNAL OF NATURAL PRODUCTS,79(2),406-411.
MLA	Jiao, Wei-Hua,et al."Dysiherbols A-C and Dysideanone E, Cytotoxic and NF-kappa B Inhibitory Tetracyclic Meroterpenes from a Dysidea sp Marine Sponge".JOURNAL OF NATURAL PRODUCTS 79.2(2016):406-411.