EFFECT OF CHOLINESTERASE INHIBITION IN-VITRO BY HUPERZINE ANALOGS

	EFFECT OF CHOLINESTERASE INHIBITION IN-VITRO BY HUPERZINE ANALOGS
	TANG, XC; XU, H; FENG, J; ZHOU, TX; LIU, JS
刊名	ACTA PHARMACOLOGICA SINICA
	1994-03
卷号	15 期号:2 页码:107-110
关键词	HUPERZINE PHYSOSTIGMINE GALANTHAMINE ISOFLUROPHATE ERYTHROCYTE MEMBRANE CHOLINESTERASE INHIBITORS STRUCTURE-ACTIVITY RELATIONSHIP
ISSN号	0253-9756
文献子类	Article
英文摘要	Huperzine (Hup) A and B were first discovered and studied by Chinese. Fourteen analogs of Hup were tested for their anticholinesterase (anti-ChE) activity by colorimetric method using rat erythrocyte membrane and serum as enzyme sources. Hup-A showed the highest anti-AChE potency. The anti-BuChE activity of (-)dihydro and (-) tetrahydro analogs were potent than those of Hup-A. Their anti-AChE activities were comparable to those of physostigmine and galanthamine. Dihydro analog inhibition was of the mixed competitive type with a K-i value of 0.12 mu mol.L(-1). Tetrahydro analog inhibition was of the competitive type with a K-i value of 0.56 mu mol.L(-1). They were different from isoflurophate to bond to AChE in a reversible manner.
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:A1994NA94100003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275104]
专题	院士及顾问专家
通讯作者	TANG, XC
作者单位	CHINESE ACAD SCI,SHANGHAI INST MAT MED,DEPT PHYTOCHEM,SHANGHAI 200031,PEOPLES R CHINA
推荐引用方式 GB/T 7714	TANG, XC,XU, H,FENG, J,et al. EFFECT OF CHOLINESTERASE INHIBITION IN-VITRO BY HUPERZINE ANALOGS[J]. ACTA PHARMACOLOGICA SINICA,1994,15(2):107-110.
APA	TANG, XC,XU, H,FENG, J,ZHOU, TX,&LIU, JS.(1994).EFFECT OF CHOLINESTERASE INHIBITION IN-VITRO BY HUPERZINE ANALOGS.ACTA PHARMACOLOGICA SINICA,15(2),107-110.
MLA	TANG, XC,et al."EFFECT OF CHOLINESTERASE INHIBITION IN-VITRO BY HUPERZINE ANALOGS".ACTA PHARMACOLOGICA SINICA 15.2(1994):107-110.