Synthesis, structure and antitumor activities of a new macrocyclic ligand with four neutral pendent groups: 1,4,7,10-tetrakisbenzyl-1,4,7,10-tetraazacyclododecane (L) and its Co, Ni and Cu complexes

doi:10.1023/A:1006948331317

	Synthesis, structure and antitumor activities of a new macrocyclic ligand with four neutral pendent groups: 1,4,7,10-tetrakisbenzyl-1,4,7,10-tetraazacyclododecane (L) and its Co, Ni and Cu complexes
	Kong, DY; Meng, LH; Song, L; Xie, YY
刊名	TRANSITION METAL CHEMISTRY
	1999-10
卷号	24 期号:5 页码:553-557
ISSN号	0340-4285
DOI	10.1023/A:1006948331317
文献子类	Article
英文摘要	A new macrocyclic ligand, 1,4,7,10-tetrakisbenzyl-1,4,7,10-tetraazacyclododecane (L) and its three new divalent metal complexes of general formula: M(NO3)(2)(L)nH(2)O [M = Co(1), Ni(2), n = 0; M = Cu(3), n = 1.5] have been synthesized and characterized by elemental analysis, i.r., EI mass spectra and molecular conductance. Complex (2) has been characterized by X-ray diffraction. In complex (2), the central (NiI)-I-I atom coordinatively bonds to four nitrogen atoms of the macrocyclic ligand and two oxygen atoms of nitrate anion, to form a distorted octahedron. X-ray diffraction indicated that the bonds Ni-N(1), Ni-N(2), Ni-N(3) and Ni-N(4) are of almost equal length, i.e. 2.11(1), 2.12(1), 2.10(1) and 2.17(1) Angstrom, respectively. Bond lengths of Ni-O(1) and Ni-O(2) are 2.11(1) and 2.10(1) Angstrom. Preliminary pharmacological tests show that these complexes have high antitumor activity towards HL-60 tumor cell lines.
WOS关键词	LANTHANIDE(III)
WOS研究方向	Chemistry
语种	英语
出版者	KLUWER ACADEMIC PUBL
WOS记录号	WOS:000082822700010
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274689]
专题	院士及顾问专家
通讯作者	Xie, YY
作者单位	Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Kong, DY,Meng, LH,Song, L,et al. Synthesis, structure and antitumor activities of a new macrocyclic ligand with four neutral pendent groups: 1,4,7,10-tetrakisbenzyl-1,4,7,10-tetraazacyclododecane (L) and its Co, Ni and Cu complexes[J]. TRANSITION METAL CHEMISTRY,1999,24(5):553-557.
APA	Kong, DY,Meng, LH,Song, L,&Xie, YY.(1999).Synthesis, structure and antitumor activities of a new macrocyclic ligand with four neutral pendent groups: 1,4,7,10-tetrakisbenzyl-1,4,7,10-tetraazacyclododecane (L) and its Co, Ni and Cu complexes.TRANSITION METAL CHEMISTRY,24(5),553-557.
MLA	Kong, DY,et al."Synthesis, structure and antitumor activities of a new macrocyclic ligand with four neutral pendent groups: 1,4,7,10-tetrakisbenzyl-1,4,7,10-tetraazacyclododecane (L) and its Co, Ni and Cu complexes".TRANSITION METAL CHEMISTRY 24.5(1999):553-557.