Comparative 28-day repeated oral toxicity of Longdan Xieganwan, Akebia trifoliate (Thunb.) koidz., Akebia quinata (Thunb.) Decne. and Caulis aristolochiae manshuriensis in mice

doi:10.1016/j.jep.2008.05.037

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	Comparative 28-day repeated oral toxicity of Longdan Xieganwan, Akebia trifoliate (Thunb.) koidz., Akebia quinata (Thunb.) Decne. and Caulis aristolochiae manshuriensis in mice
	Xue, Xiang 2,3; Xiao, Ying 2,3; Gong, Likun2 ; Guan, Shuhong1 ; Liu, Yongzhen2 ; Lu, Henglei 2; Qi, Xinming2 ; Zhang, Yunhai 2,3; Li, Yan 2,3; Wua, Xiongfei 2,3
刊名	JOURNAL OF ETHNOPHARMACOLOGY
	2008-09-02
卷号	119 期号:1 页码:87-93
关键词	oral toxicity Longdan Xieganwan Akebia trifoliate (Thunb.) koidz. Akebia quinata (Thunb.) Decne. Caulis aristolochiae manshuriensis no-observed-adverse-effect level
ISSN号	0378-8741
DOI	10.1016/j.jep.2008.05.037
文献子类	Article
英文摘要	Ethnopharmacological relevance: Longdan Xieganwan, which contains Aristolochia species, is a traditional Chinese prescription. It has been used for thousands of years to "enhance liver". However, many cases of Longdan Xieganwan induced nephropathy were reported recently. Aim of the study: This study was designed to compare the possible toxic effects of Longdan Xieganwan and three different Aristolochia species. i.e. Akebia trifoliate (Thunb.) koid (Akebia trifoliate), Akebia quinata (Thunb.) Decne. (Akebia quinata) and Caulis aristolochiae manshuriensis (Aristolochia manshuriensis). Materials and methods: Mice were orally administered these drugs for 28 days. Clinical signs, body weights, serum biochemistry, organ weights and histopathology were examined. Results: Significantly decreased body weights and obvious nephropathy were noticed in the Aristolochia manshuriensis groups at doses higher than 0.24g/kg/d. A few endothelial cell degenerations in renal glomerulus were observed in the Akebia trifoliate group at a high-dose of 2.00 g/kg/d. No significant changes were observed in the other groups. Conclusions: The no-observed-adverse-effect levels (NOAELs) for Aristolochia manshuriensis, Akebia trifoliate, Akebia quinata and Longdan Xieganwan in this study for mice were 0.06 g/kg/d, 0.40 g/kg/d, higher than 3.00 g/kg/d and higher than 10.00 g/kg/d, which were equivalent to 0.25 times, 5 times, 25 times and 10 times of normal human dose in clinical prescription, respectively. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
资助项目	National Grand Fundamental Research 973 Program of China[2006CB504700]
WOS关键词	CHINESE HERBS ; NEPHROPATHY ; ACIDS ; FIBROSIS ; LESSONS
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
语种	英语
出版者	ELSEVIER IRELAND LTD
WOS记录号	WOS:000259336600013
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272813]
专题	药物安全性评价中心
通讯作者	Ren, Jin
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab New Drug Res, Ctr Drug Safety & Evaluat, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Grad Sch, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Xue, Xiang,Xiao, Ying,Gong, Likun,et al. Comparative 28-day repeated oral toxicity of Longdan Xieganwan, Akebia trifoliate (Thunb.) koidz., Akebia quinata (Thunb.) Decne. and Caulis aristolochiae manshuriensis in mice[J]. JOURNAL OF ETHNOPHARMACOLOGY,2008,119(1):87-93.
APA	Xue, Xiang.,Xiao, Ying.,Gong, Likun.,Guan, Shuhong.,Liu, Yongzhen.,...&Ren, Jin.(2008).Comparative 28-day repeated oral toxicity of Longdan Xieganwan, Akebia trifoliate (Thunb.) koidz., Akebia quinata (Thunb.) Decne. and Caulis aristolochiae manshuriensis in mice.JOURNAL OF ETHNOPHARMACOLOGY,119(1),87-93.
MLA	Xue, Xiang,et al."Comparative 28-day repeated oral toxicity of Longdan Xieganwan, Akebia trifoliate (Thunb.) koidz., Akebia quinata (Thunb.) Decne. and Caulis aristolochiae manshuriensis in mice".JOURNAL OF ETHNOPHARMACOLOGY 119.1(2008):87-93.