Calcium Promotes Human Gastric Cancer via a Novel Coupling of Calcium-Sensing Receptor and TRPV4 Channel

doi:10.1158/0008-5472.CAN-17-0360

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	Calcium Promotes Human Gastric Cancer via a Novel Coupling of Calcium-Sensing Receptor and TRPV4 Channel
	Xie, Rui 1,2; Xu, Jingyu 2; Xiao, Yufeng 1; Wu, Jilin 3; Wan, Hanxing 1; Tang, Bo 1; Liu, Jingjing 1; Fan, Yahan 1; Wang, Suming 1; Wu, Yuyun 1
刊名	CANCER RESEARCH
	2017-12-01
卷号	77 期号:23 页码:6499-6512
ISSN号	0008-5472
DOI	10.1158/0008-5472.CAN-17-0360
文献子类	Article
英文摘要	Although dietary calcium intake has long been recommended for disease prevention, the influence of calcium in development of cancer in the upper gastrointestinal tract has not been explored. Here, we assess the roles of calcium and calcium-sensing receptor (CaSR) in gastric cancer development. CaSR expression was enhanced in gastric cancer specimens, which positively correlated with serum calcium concentrations, tumor progression, poor survival, and male gender in gastric cancer patients. CaSR and transient receptor potential cation channel subfamily V member 4 (TRPV4) were colocalized in gastric cancer cells, and CaSR activation evoked TRPV4-mediated Ca2+ entry. Both CaSR and TRPV4 were involved in Ca2+-induced proliferation, migration, and invasion of gastric cancer cells through a Ca2+/AKT/beta-catenin relay, which occurred only in gastric cancer cells or normal cells overexpressing CaSR. Tumor growth and metastasis of gastric cancer depended on CaSR in nude mice. Overall, our findings indicate that calcium may enhance expression and function of CaSR to potentially promote gastric cancer, and that targeting the novel CaSR/TRPV4/Ca2+ pathway might serve as preventive or therapeutic strategies for gastric cancer. (C) 2017 AACR.
资助项目	National Natural Science Foundation of China[81301731] ; National Key Research and Development Program of China[2016YFC1302200]
WOS关键词	EXTRACELLULAR CALCIUM ; CELL-PROLIFERATION ; THERAPEUTIC TARGET ; SIGNALING PATHWAY ; CASR ; CARCINOGENESIS ; TUMORIGENESIS ; INFLAMMATION ; ACTIVATION ; REGULATOR
WOS研究方向	Oncology
语种	英语
出版者	AMER ASSOC CANCER RESEARCH
WOS记录号	WOS:000416854100004
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272375]
专题	神经药理学研究国际科学家工作站
通讯作者	Dong, Hui; Yang, Shiming
作者单位	1.Third Mil Med Univ, Xinqiao Hosp, Dept Gastroenterol, Chongqing, Peoples R China; 2.Zunyi Med Coll, Dept Gastroenterol, Affiliated Hosp, Zunyi, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China; 4.Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA 5.Univ Texas Hlth Sci Ctr Houston, Dept Integrat Biol & Pharmacol, Houston, TX 77030 USA; 6.Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA;
推荐引用方式 GB/T 7714	Xie, Rui,Xu, Jingyu,Xiao, Yufeng,et al. Calcium Promotes Human Gastric Cancer via a Novel Coupling of Calcium-Sensing Receptor and TRPV4 Channel[J]. CANCER RESEARCH,2017,77(23):6499-6512.
APA	Xie, Rui.,Xu, Jingyu.,Xiao, Yufeng.,Wu, Jilin.,Wan, Hanxing.,...&Yang, Shiming.(2017).Calcium Promotes Human Gastric Cancer via a Novel Coupling of Calcium-Sensing Receptor and TRPV4 Channel.CANCER RESEARCH,77(23),6499-6512.
MLA	Xie, Rui,et al."Calcium Promotes Human Gastric Cancer via a Novel Coupling of Calcium-Sensing Receptor and TRPV4 Channel".CANCER RESEARCH 77.23(2017):6499-6512.