Absorption, distribution, metabolism, excretion and toxicity of biologics and its application in pharmacokinetic modeling

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	Absorption, distribution, metabolism, excretion and toxicity of biologics and its application in pharmacokinetic modeling
	Zhang Cuifeng 1; Xie Haitang 2; Pan Guoyu3
刊名	Acta Pharmaceutica Sinica
	2016
卷号	51 期号:8 页码:1202-1208
关键词	macromolecule pharmacokinetics model monoclonal antibodies
ISSN号	0513-4870
其他题名	大分子药物的吸收、分布、代谢、排泄和毒性特征及药代模型的应用
文献子类	Review
英文摘要	Recently, more and more attentions of drug development are placed to macromolecules, such as monoclonal antibodies, proteins, etc. It has become one of the most promising areas in drug research and development in 21st Century. In terms of the structure and the ADMET (absorption, distribution, metabolism, excretion and toxicity), macromolecules is different from small molecule drugs, which lead to a distinct modeling strategy. The characterization of biologics ADMET processes and its application in the PK model selection of macromolecules are reviewed in this paper.
资助项目	国家自然科学基金资助项目[00000000] ; 安徽高校自然科学研究项目[00000000] ; 2016年高校优秀青年人才支持计划重点项目[00000000]
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:5768137
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/269245]
专题	药物安全性评价中心
通讯作者	Pan Guoyu
作者单位	1.Wannan Medical College, Wuhu, Anhui 241000, China.; 2.Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241000, China.; 3.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200120, China.
推荐引用方式 GB/T 7714	Zhang Cuifeng,Xie Haitang,Pan Guoyu. Absorption, distribution, metabolism, excretion and toxicity of biologics and its application in pharmacokinetic modeling[J]. Acta Pharmaceutica Sinica,2016,51(8):1202-1208.
APA	Zhang Cuifeng,Xie Haitang,&Pan Guoyu.(2016).Absorption, distribution, metabolism, excretion and toxicity of biologics and its application in pharmacokinetic modeling.Acta Pharmaceutica Sinica,51(8),1202-1208.
MLA	Zhang Cuifeng,et al."Absorption, distribution, metabolism, excretion and toxicity of biologics and its application in pharmacokinetic modeling".Acta Pharmaceutica Sinica 51.8(2016):1202-1208.