Absorption, distribution, metabolism, excretion and toxicity of biologics and its application in pharmacokinetic modeling | |
Zhang Cuifeng1; Xie Haitang2; Pan Guoyu3![]() | |
刊名 | Acta Pharmaceutica Sinica
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2016 | |
卷号 | 51期号:8页码:1202-1208 |
关键词 | macromolecule pharmacokinetics model monoclonal antibodies |
ISSN号 | 0513-4870 |
其他题名 | 大分子药物的吸收、分布、代谢、排泄和毒性特征及药代模型的应用 |
文献子类 | Review |
英文摘要 | Recently, more and more attentions of drug development are placed to macromolecules, such as monoclonal antibodies, proteins, etc. It has become one of the most promising areas in drug research and development in 21st Century. In terms of the structure and the ADMET (absorption, distribution, metabolism, excretion and toxicity), macromolecules is different from small molecule drugs, which lead to a distinct modeling strategy. The characterization of biologics ADMET processes and its application in the PK model selection of macromolecules are reviewed in this paper. |
资助项目 | 国家自然科学基金资助项目[00000000] ; 安徽高校自然科学研究项目[00000000] ; 2016年高校优秀青年人才支持计划重点项目[00000000] |
WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
语种 | 中文 |
CSCD记录号 | CSCD:5768137 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/269245] ![]() |
专题 | 药物安全性评价中心 |
通讯作者 | Pan Guoyu |
作者单位 | 1.Wannan Medical College, Wuhu, Anhui 241000, China.; 2.Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241000, China.; 3.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200120, China. |
推荐引用方式 GB/T 7714 | Zhang Cuifeng,Xie Haitang,Pan Guoyu. Absorption, distribution, metabolism, excretion and toxicity of biologics and its application in pharmacokinetic modeling[J]. Acta Pharmaceutica Sinica,2016,51(8):1202-1208. |
APA | Zhang Cuifeng,Xie Haitang,&Pan Guoyu.(2016).Absorption, distribution, metabolism, excretion and toxicity of biologics and its application in pharmacokinetic modeling.Acta Pharmaceutica Sinica,51(8),1202-1208. |
MLA | Zhang Cuifeng,et al."Absorption, distribution, metabolism, excretion and toxicity of biologics and its application in pharmacokinetic modeling".Acta Pharmaceutica Sinica 51.8(2016):1202-1208. |
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