Synthetic process of telavancin | |
Xiong Lun2; Guan Dongliang1; Li Jian2; Huang Wei1 | |
刊名 | Journal of China Pharmaceutical University |
2017 | |
卷号 | 48期号:2页码:172-177 |
关键词 | vancomycin telavancin synthetic process |
ISSN号 | 1000-5048 |
其他题名 | 特拉万星合成工艺研究 |
文献子类 | Article |
英文摘要 | New process reported the synthesis of telavancin using decyl alcohol as the starting material.After methanesulfonylation,nucleophilic substitution with ethanolamine,Fmoc protection,and Parikh-Doering oxidation,the intermdiate N-(9-fluorenyl-9-methoxycarbonyl) decylaminoethyl acetaldehyde (5) was obtained.Vancomycin hydrochloride and intermediate 5 were then subject to reductive amination reaction,Fmoc deprotection,and Mannich reaction to give the telavancin product.The process have been deeply studied on the two key reactions of reductive amination and Mannich reaction,and the reaction conditions have been optimized.The overall yield is 46% based on starting material vancomycin. |
资助项目 | 国家自然科学基金资助项目[00000000] |
WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
语种 | 中文 |
CSCD记录号 | CSCD:5964872 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/269208] |
专题 | 药物安全性评价中心 |
作者单位 | 1.Shanghai Institute of Materia Media,Chinese Academy of Sciences, Shanghai 201203, China. 2.College of Pharmacy,East China University of Science and Technology, Shanghai 200237, China.; |
推荐引用方式 GB/T 7714 | Xiong Lun,Guan Dongliang,Li Jian,et al. Synthetic process of telavancin[J]. Journal of China Pharmaceutical University,2017,48(2):172-177. |
APA | Xiong Lun,Guan Dongliang,Li Jian,&Huang Wei.(2017).Synthetic process of telavancin.Journal of China Pharmaceutical University,48(2),172-177. |
MLA | Xiong Lun,et al."Synthetic process of telavancin".Journal of China Pharmaceutical University 48.2(2017):172-177. |
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