Research development of cytokine release syndrome induced by monoclonal antibody and cytokine release assays in vitro

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	Research development of cytokine release syndrome induced by monoclonal antibody and cytokine release assays in vitro
	Yu Xiaolu 1; Sun Jianhua1 ; Gong Likun1
刊名	Chinese Pharmacological Bulletin
	2018
卷号	34 期号:9 页码:1185-1189
关键词	TGN1412 monoclonal antibody cytokine-release syndrome TGN1412 cytokine release assay in vitro minimum anticipated biological effect level preclinical safety study
ISSN号	1001-1978
其他题名	单抗诱发性细胞因子释放综合征和体外细胞因子释放实验的研究进展
文献子类	Review
英文摘要	Cytokine-release syndrome (CRS) triggered by monoclonal antibodies (mAbs) is characterized by rapid onset and severe damage,and difficulty in prediction and control. Recent years, it has been a research focus on establishing a reliable animal model in vivo and cytokine release assay(CRA) in vitro to predict CRS for preclinical safety evaluation. In this paper we summarize matters related to CRA applicable objects,considerations of method design and method optimization,aiming to provide suggestions for the optimization of CRA prediction platform.
资助项目	国家科技部重大新药创制科技重大专项[00000000] ; 中科院药物所创新研究院自主部署项目[00000000]
WOS研究方向	General & Internal Medicine (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:6323339
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/269159]
专题	药物安全性评价中心
通讯作者	Gong Likun
作者单位	1.School of Pharmacy,University of Chinese Academy of Sciences; 2.Beijing 3.Shanghai Institute of Materia Medica,Chinese Academy of Sciences,; 4.;
推荐引用方式 GB/T 7714	Yu Xiaolu,Sun Jianhua,Gong Likun. Research development of cytokine release syndrome induced by monoclonal antibody and cytokine release assays in vitro[J]. Chinese Pharmacological Bulletin,2018,34(9):1185-1189.
APA	Yu Xiaolu,Sun Jianhua,&Gong Likun.(2018).Research development of cytokine release syndrome induced by monoclonal antibody and cytokine release assays in vitro.Chinese Pharmacological Bulletin,34(9),1185-1189.
MLA	Yu Xiaolu,et al."Research development of cytokine release syndrome induced by monoclonal antibody and cytokine release assays in vitro".Chinese Pharmacological Bulletin 34.9(2018):1185-1189.