Inclusion complex of 2-hydroxypropyl-beta-cyclodextrin with a new chemical entity NE-2001 against Helicobacter pylori

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	Inclusion complex of 2-hydroxypropyl-beta-cyclodextrin with a new chemical entity NE-2001 against Helicobacter pylori
	Dai Guofei 2; Zhao Weiqiang 3; Chen Jie 3; Xie Jianshu 1; Wang Mingwei2
刊名	Chinese Journal New Drugs
	2006
卷号	15 期号:19 页码:1664-1668
关键词	2-hydroxypropyl-beta-cyclodextrin inclusion complex lyophilize X-ray diffraction differential scanning calorimetry（DSC）
ISSN号	1003-3734
其他题名	2-羟丙基-beta-环糊精包合抗幽门螺杆菌新化学实体NE-2001的实验研究
文献子类	Article
英文摘要	Objective： To optimize the preparation of an inclusion complex of NE-2001, a new chemical entity against Helicobacter pylori, using 2-hydroxypropyl-beta-cyclodextrin (2-HP-beta-CD). Methods ： The process for the inclusion complex of NE-2001 with 2-HP-beta-CD were optimized using an orthogonal test; the target inclusion complex was prepared by a lyophilizing technique. The quality of the inclusion complex was determined by X-ray diffraction (XRD) and differential scanning calorimetry (DSC) as well as comparison with other three types of cyclodextrins. Results： The optimal parameters of the process for the inclusion complex included a molar ratio of 2-HP-beta-CD to NE-2001 5： 1, reaction temperature at 50 ℃ and inclusion period for 45 min. Under these conditions, the inclusion complex had maximal values of solubility and reaction constant Kc. XRD and DSC analyses confirmed that the lyophilizing powder had features of an inclusion complex. Conclusion： The solubility of NE-2001 was significantly improved as a result of the inclusion complex with 2-HP-beta-CD.
资助项目	国家重大科技专项[00000000] ; 中国科学院知识创新工程重大项目[00000000] ; 上海市科学技术发展基金[00000000]
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:2640645
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/268190]
专题	国家新药筛选中心
作者单位	1.Shanghai East Best Biopharmaceutical Enterprises Co. , Ltd., Shanghai 200233, China. 2.The National Center for Drug Screening, Shanghai Institute of Materia Medica and the Graduate School, Chinese Academy of Sciences, Shanghai 201203, China.; 3.Zhefiang Xianju Pharmaceutical Co. , Ltd., Xianju, 317300.;
推荐引用方式 GB/T 7714	Dai Guofei,Zhao Weiqiang,Chen Jie,et al. Inclusion complex of 2-hydroxypropyl-beta-cyclodextrin with a new chemical entity NE-2001 against Helicobacter pylori[J]. Chinese Journal New Drugs,2006,15(19):1664-1668.
APA	Dai Guofei,Zhao Weiqiang,Chen Jie,Xie Jianshu,&Wang Mingwei.(2006).Inclusion complex of 2-hydroxypropyl-beta-cyclodextrin with a new chemical entity NE-2001 against Helicobacter pylori.Chinese Journal New Drugs,15(19),1664-1668.
MLA	Dai Guofei,et al."Inclusion complex of 2-hydroxypropyl-beta-cyclodextrin with a new chemical entity NE-2001 against Helicobacter pylori".Chinese Journal New Drugs 15.19(2006):1664-1668.