The pseudoendogenous anabolic steroid 1,4-androstadiene-3,17-dione does not occur naturally in Rhodiola rosea L. radix and rhizome

doi:10.1016/j.phytol.2017.12.007

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	The pseudoendogenous anabolic steroid 1,4-androstadiene-3,17-dione does not occur naturally in Rhodiola rosea L. radix and rhizome
	Da, Juan 2; Yang, Lin 2; Wu, Wan-ying2 ; Guo, De-an2 ; Panossian, Alexander G.1,3
刊名	PHYTOCHEMISTRY LETTERS
	2018-02
卷号	23 页码:155-163
关键词	1,4-Androstadiene-3,17-dione Rhodiola rosea Doping
ISSN号	1874-3900
DOI	10.1016/j.phytol.2017.12.007
文献子类	Article
英文摘要	Background: Rhodiola rosea L. roots and rhizome (RRR) extracts are used as dietary supplements for temporary relief of symptoms of stress, such as fatigue, sensation of weakness, and for improvement of mental and cognitive function. RRR containing products are also of interest to sports nutrition experts and antidoping authorities. It has been suggested that nutritional supplements containing Rhodiola rosea extracts be examined for the presence of (pseudo-) endogenous steroids, specifically for the presence of 1,4-androstadiene-3,17-dione (ADD) which can potentially lead to adverse analytical findings (AAFs) in doping controls. Aim of the study: The aim of the present study was to detect and quantify ADD in Rhodiola roots and rhizomes collected in various geographical locations of North America, Europe, and Asia. Results: ADD was not found in RRR by any of three methods used in this study. No peaks corresponding to ADD in chromatograms of RRR extract were detected at the limit of quantification corresponding to 1.6 ng/g of ADD in dry rhizomes of Rhodiola rosea. Conclusion: The anabolic steroid 1,4-androstadiene-3,17-dione was not detectable in the Rhodiola rosea roots and rhizomes, at least not present in amounts which may be a concern for athletes who want to avoid the consumption of this anabolic agent with Rhodiola dietary supplementation.
资助项目	Shanghai Research Center for TCM Modernization at the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China[00000000] ; Swedish Herbal Institute Research and Development, Kovlingevagen, Vallberga, Sweden[00000000]
WOS关键词	ADAPTOGENS ; EFFICACY ; ANDROSTENEDIONE ; PERFORMANCE ; SUPPLEMENTS ; BOLDENONE ; EXERCISE
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000426096600029
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279923]
专题	上海中药现代化研究中心
通讯作者	Guo, De-an; Panossian, Alexander G.
作者单位	1.EuroPharmaUSA Inc, 955 Challenger Dr, Green Bay, WI 54311 USA 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr TCM Modernizat, Beijing, Peoples R China; 3.Swedish Herbal Inst Res & Dev, Kovlingevagen 21, S-31250 Vallberga, Sweden;
推荐引用方式 GB/T 7714	Da, Juan,Yang, Lin,Wu, Wan-ying,et al. The pseudoendogenous anabolic steroid 1,4-androstadiene-3,17-dione does not occur naturally in Rhodiola rosea L. radix and rhizome[J]. PHYTOCHEMISTRY LETTERS,2018,23:155-163.
APA	Da, Juan,Yang, Lin,Wu, Wan-ying,Guo, De-an,&Panossian, Alexander G..(2018).The pseudoendogenous anabolic steroid 1,4-androstadiene-3,17-dione does not occur naturally in Rhodiola rosea L. radix and rhizome.PHYTOCHEMISTRY LETTERS,23,155-163.
MLA	Da, Juan,et al."The pseudoendogenous anabolic steroid 1,4-androstadiene-3,17-dione does not occur naturally in Rhodiola rosea L. radix and rhizome".PHYTOCHEMISTRY LETTERS 23(2018):155-163.