Antiplasmodial Isoflavanones from the Roots of Sophora mollis

doi:10.1021/np900144c

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	Antiplasmodial Isoflavanones from the Roots of Sophora mollis
	Zhang, Gui-Ping 2; Xiao, Zhi-Yong 2; Rafique, Jamal 1; Arfan, Mohammad 1; Smith, Peter J.3; Lategan, Carmen A.3; Hu, Li-Hong 2
刊名	JOURNAL OF NATURAL PRODUCTS
	2009-07
卷号	72 期号:7 页码:1265-1268
ISSN号	0163-3864
DOI	10.1021/np900144c
文献子类	Article
英文摘要	Six new prenylated isoflavanones named sophoronols A-F (1-6), together with eight phenolic constituents, were isolated from the roots of Sophora mollis. Their structures and stereochemistry were established by 1D and 2D NMR techniques, especially HMBC and NOESY as well as CD results. Componds 3 and 5 exhibited moderate anitplasmodial activity against the CQS D 10 strain of Plasmodium falciparum, with IC50 values of 12.9 and 12.8 mu M, respectively.
资助项目	Higher Education Commission, Pakistan[00000000] ; Chinese National High-tech RD Program[2007AA02Z147] ; Chinese National High-tech RD Program[2006AA020602] ; National Natural Science Foundation of China[90713046] ; National Natural Science Foundation of China[30772638] ; CAS Foundation[KSCX2-YW-R-18]
WOS关键词	ISOFLAVONES ; FLAVONOIDS ; FLAVESCENS ; ASSAY
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000268664500008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279199]
专题	上海中药现代化研究中心
通讯作者	Arfan, Mohammad
作者单位	1.Univ Peshawar, Inst Chem Sci, Peshawar, Pakistan; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China; 3.Univ Cape Town, Dept Med, ZA-7925 Observatory, South Africa
推荐引用方式 GB/T 7714	Zhang, Gui-Ping,Xiao, Zhi-Yong,Rafique, Jamal,et al. Antiplasmodial Isoflavanones from the Roots of Sophora mollis[J]. JOURNAL OF NATURAL PRODUCTS,2009,72(7):1265-1268.
APA	Zhang, Gui-Ping.,Xiao, Zhi-Yong.,Rafique, Jamal.,Arfan, Mohammad.,Smith, Peter J..,...&Hu, Li-Hong.(2009).Antiplasmodial Isoflavanones from the Roots of Sophora mollis.JOURNAL OF NATURAL PRODUCTS,72(7),1265-1268.
MLA	Zhang, Gui-Ping,et al."Antiplasmodial Isoflavanones from the Roots of Sophora mollis".JOURNAL OF NATURAL PRODUCTS 72.7(2009):1265-1268.