Characterization of anti-Coxsackie virus B3 constituents of Radix Astragali by highperformance liquid chromatography coupled with electrospray ionization tandem mass spectrometry

doi:10.1002/bmc.1400

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	Characterization of anti-Coxsackie virus B3 constituents of Radix Astragali by highperformance liquid chromatography coupled with electrospray ionization tandem mass spectrometry
	Ye, Guan; Tang, Yi-Hong; Xia, Guang-Xin; Sun, Zhao-Lin; Li, Zhi-Xiong; Huang, Cheng-Gang
刊名	BIOMEDICAL CHROMATOGRAPHY
	2010-11
卷号	24 期号:11 页码:1147-1151
关键词	Radix Astragali Coxsackie virus B3 drug screening isoflavonoid saponin HPLC-DAD-MSn
ISSN号	0269-3879
DOI	10.1002/bmc.1400
文献子类	Article
英文摘要	To profile the anti-Coxsackie virus B3 constituents of Radix Astragali, an HPLC-DAD-MSn analytical method, combined with an in vivo test, has been developed to identify the constituents of the active part, which has been demonstrated to have potency to inhibit the proliferation of virus in cardiac muscle, alleviate infraction in heart and elevate the survival rate of the animal By comparing their retention time and MS data with those obtained from the authentic compounds and the published data, a total of 19 compounds, including 11 isoflavonoids and eight saponins, were identified, among which one pterocarpane glucoside was reported for the first time The present study provides an approach to rapidly screening bioactive constituents in traditional Chinese medicines Copyright (C) 2010 John Wiley & Sons, Ltd
资助项目	National Science & Technology Marjor Project "Key New Drug Creation and Manufacturing Program", China[2009ZX09301-001] ; National Natural Science Foundation of China[30500655]
WOS关键词	ISOFLAVONOIDS ; ARRAY ; EXTRACTION ; PRODUCTS ; ROOTS
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	WILEY
WOS记录号	WOS:000283761400001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278730]
专题	上海中药现代化研究中心
通讯作者	Huang, Cheng-Gang
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Ye, Guan,Tang, Yi-Hong,Xia, Guang-Xin,et al. Characterization of anti-Coxsackie virus B3 constituents of Radix Astragali by highperformance liquid chromatography coupled with electrospray ionization tandem mass spectrometry[J]. BIOMEDICAL CHROMATOGRAPHY,2010,24(11):1147-1151.
APA	Ye, Guan,Tang, Yi-Hong,Xia, Guang-Xin,Sun, Zhao-Lin,Li, Zhi-Xiong,&Huang, Cheng-Gang.(2010).Characterization of anti-Coxsackie virus B3 constituents of Radix Astragali by highperformance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.BIOMEDICAL CHROMATOGRAPHY,24(11),1147-1151.
MLA	Ye, Guan,et al."Characterization of anti-Coxsackie virus B3 constituents of Radix Astragali by highperformance liquid chromatography coupled with electrospray ionization tandem mass spectrometry".BIOMEDICAL CHROMATOGRAPHY 24.11(2010):1147-1151.