Biotransformation of arenobufagin and cinobufotalin by Alternaria alternata

doi:10.3109/10242422.2011.578248

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	Biotransformation of arenobufagin and cinobufotalin by Alternaria alternata
	Zhang, Xing 3,4; Ye, Min 3; Dong, Yin-Hui 5; Hu, Hong-Bo 5; Tao, Si-Jia 2; Chen, Guang-Tong 1; Yin, Jun 4; Guo, De-An2,3
刊名	BIOCATALYSIS AND BIOTRANSFORMATION
	2011-03
卷号	29 期号:2-3 页码:96-101
关键词	Arenobufagin cinobufotalin biotransformation Alternaria alternata isomerization
ISSN号	1024-2422
DOI	10.3109/10242422.2011.578248
文献子类	Article
英文摘要	The biotransformation of arenobufagin (1) and cinobufotalin (2), isolated from the natural medicine Chan Su, by Alternaria alternata AS 3.4578 was carried out. Incubation of 1 and 2 afforded six metabolites: 3-oxo-arenobufagin (1a), psi-bufarenogin (1b), 3-oxo-psi-bufarenogin (1c), 3-oxo-Delta(4)-derivative of cinobufotalin (2a), 3-oxo-cinobufotalin (2b) and 12 beta-hydroxycinobufotalin (2c). Among them, metabolites 1a, 1c and 2c are new compounds and their structures were characterized on the basis of their spectroscopic data (NMR, MS and IR). Compounds 1, 2, 1b, 2a and 2b were evaluated for their cytotoxicity against HepG2 and MCF-7 human cancer cells, and all of them showed significant inhibitory activities.
资助项目	Beijing NOVA Program[2009B02] ; Research Fund for Doctoral Program of Higher Education in China[00000000] ; National Science & Technology Major Project of China[2009ZX09304-002]
WOS关键词	CYTOTOXIC BUFADIENOLIDES ; MICROBIAL TRANSFORMATION ; CATHARANTHUS-ROSEUS ; CINOBUFAGIN ; CHROMATOGRAPHY ; HYDROXYLATION ; PURIFICATION ; BUFALIN ; NMR
WOS研究方向	Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
语种	英语
出版者	INFORMA HEALTHCARE
WOS记录号	WOS:000290868200008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278587]
专题	上海中药现代化研究中心
通讯作者	Ye, Min
作者单位	1.Med Sch Nantong Univ, Nantong, Peoples R China 2.Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Med, Shanghai, Peoples R China; 3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China; 4.Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang, Peoples R China; 5.China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100094, Peoples R China;
推荐引用方式 GB/T 7714	Zhang, Xing,Ye, Min,Dong, Yin-Hui,et al. Biotransformation of arenobufagin and cinobufotalin by Alternaria alternata[J]. BIOCATALYSIS AND BIOTRANSFORMATION,2011,29(2-3):96-101.
APA	Zhang, Xing.,Ye, Min.,Dong, Yin-Hui.,Hu, Hong-Bo.,Tao, Si-Jia.,...&Guo, De-An.(2011).Biotransformation of arenobufagin and cinobufotalin by Alternaria alternata.BIOCATALYSIS AND BIOTRANSFORMATION,29(2-3),96-101.
MLA	Zhang, Xing,et al."Biotransformation of arenobufagin and cinobufotalin by Alternaria alternata".BIOCATALYSIS AND BIOTRANSFORMATION 29.2-3(2011):96-101.