Ullmann-type C-N coupling reaction catalyzed by CuI/metformin

doi:10.1016/j.tet.2014.10.014

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	Ullmann-type C-N coupling reaction catalyzed by CuI/metformin
	Zhang, Chao 1; Zhan, Zhajun 1; Lei, Min2 ; Hu, Lihong 1,2
刊名	TETRAHEDRON
	2014-11-18
卷号	70 期号:46 页码:8817-8821
关键词	Amine Aryl halide C-N coupling reaction Metformin Ullmann-type reaction
ISSN号	0040-4020
DOI	10.1016/j.tet.2014.10.014
文献子类	Article
英文摘要	A facile and efficient method for Ullmann-type C-N coupling reaction of amine and aryl halide catalyzed by CuI/metformin in EtOH is described. The advantages of this method are the use of an inexpensive and readily available catalyst and ligand, easy workup, shorter reaction time, improved yields, and the use of green solvent. Furthermore, this procedure is applied successfully for the modification of natural products, such as Vindoline and Tabersonin. (C) 2014 Elsevier Ltd. All rights reserved.
资助项目	National Natural Science Foundation of China[30925040] ; National Natural Science Foundation of China[81102329] ; National Natural Science Foundation of China[81273397] ; Chinese National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program'[2013ZX09508104] ; Chinese National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program'[2012ZX09301001-001] ; Chinese National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program'[2011ZX09307-002-03] ; Science Foundation of Shanghai[12XD1405700]
WOS关键词	ARYL IODIDES ; HIGHLY EFFICIENT ; ALIPHATIC-AMINES ; ROOM-TEMPERATURE ; ALKYLAMINES ; ARYLATION ; LIGAND ; PHOSPHORAMIDITE ; IODOBENZENE ; BROMIDES
WOS研究方向	Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000344204700002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276832]
专题	上海中药现代化研究中心
通讯作者	Lei, Min
作者单位	1.Zhejiang Univ Technol, Coll Phanaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China; 2.Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Chao,Zhan, Zhajun,Lei, Min,et al. Ullmann-type C-N coupling reaction catalyzed by CuI/metformin[J]. TETRAHEDRON,2014,70(46):8817-8821.
APA	Zhang, Chao,Zhan, Zhajun,Lei, Min,&Hu, Lihong.(2014).Ullmann-type C-N coupling reaction catalyzed by CuI/metformin.TETRAHEDRON,70(46),8817-8821.
MLA	Zhang, Chao,et al."Ullmann-type C-N coupling reaction catalyzed by CuI/metformin".TETRAHEDRON 70.46(2014):8817-8821.