Synthesis and Structure-Activity Relationship Studies of Cytotoxic Ester and Ether Anhydrovinblastine Derivatives

doi:10.1021/np800284h

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 上海中药现代化研究中心

	Synthesis and Structure-Activity Relationship Studies of Cytotoxic Ester and Ether Anhydrovinblastine Derivatives
	Zhang, Han-Kun 2; Shao, Yong 2; Ding, Hong1 ; Hu, Li-Hong 2
刊名	JOURNAL OF NATURAL PRODUCTS
	2008-10
卷号	71 期号:10 页码:1669-1676
ISSN号	0163-3864
DOI	10.1021/np800284h
文献子类	Article
英文摘要	Two new series of 3-demethoxycarbony 1-3-ester and 3-demethoxycarbonyl-3-ether methyl anhydrovinblastine derivatives were designed, synthesized, and evaluated for their inhibitory activities against human non-small-cell lung cancer (A549) and cervical epithelial adenocarcinoma (HeLa) cell lines. Ester anhydrovinblastine derivatives exhibited potent cytotoxicity, whereas the ether analogues were much less active. The size of the introduced substituents was the foremost factor in determining the resultant cytotoxic activity. Compound 12b showed a similar cytotoxic potency to the positive control, anhydrovinblastine (1a).
资助项目	Chinese National Natural Science Foundation of China[30772638] ; Chinese National High-tech RD Program[2006AA020602]
WOS关键词	ANALOGS
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000260384400002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272796]
专题	上海中药现代化研究中心
通讯作者	Hu, Li-Hong
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Mol Pharmacol, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Zhang, Han-Kun,Shao, Yong,Ding, Hong,et al. Synthesis and Structure-Activity Relationship Studies of Cytotoxic Ester and Ether Anhydrovinblastine Derivatives[J]. JOURNAL OF NATURAL PRODUCTS,2008,71(10):1669-1676.
APA	Zhang, Han-Kun,Shao, Yong,Ding, Hong,&Hu, Li-Hong.(2008).Synthesis and Structure-Activity Relationship Studies of Cytotoxic Ester and Ether Anhydrovinblastine Derivatives.JOURNAL OF NATURAL PRODUCTS,71(10),1669-1676.
MLA	Zhang, Han-Kun,et al."Synthesis and Structure-Activity Relationship Studies of Cytotoxic Ester and Ether Anhydrovinblastine Derivatives".JOURNAL OF NATURAL PRODUCTS 71.10(2008):1669-1676.