Activation of dendritic cells by low molecular weight oyster polysaccharides

doi:10.1016/j.intimp.2017.01.018

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	Activation of dendritic cells by low molecular weight oyster polysaccharides
	Zhong, Ming 1; Zhong, Cheng 6; Wang, Tingting 5; Hu, Pei 4; Wang, Guanghui 1; Ren, Rujing 1; Zhang, Jing 1; Gao, Huijei 1; Cui, Wen 1; Duan, Wenjuan 3
刊名	INTERNATIONAL IMMUNOPHARMACOLOGY
	2017-03
卷号	44 页码:183-190
关键词	Polysaccharides Oyster Dendritic cells Maturation MAPK
ISSN号	1567-5769
DOI	10.1016/j.intimp.2017.01.018
文献子类	Article
英文摘要	Dendritic cells play a primary role in antigen presentation to CD4(+) T cells, which initiate acquired immune responses. Therefore, determining positive modulators of dendritic cell activation to improve therapeutic approaches for cancer treatment might be useful. We here investigated the effects of low molecular weight oyster polysaccharides (LMW-OPS) on bone marrow-derived dendritic cells (BMDCs) obtained from mice. LMW-OPS increased the surface expression of major histocompatibility complex class II (MHC-II), CD40 and CD86 in BMDCs and induced the secretion of tumour necrosis factor (TNF)-alpha and interleukin (IL)-12, which were significantly decreased in the BMDCs derived from MyD88(-/)-mice but not from the lipopolysaccharide-resistant C3H/HeJ mice. BMDCs treated with LMW-OPS augmented allogeneic CD4(+) T cell expansion and enhanced secretion of IL-2 and interferon (IFN)-gamma but not IL-4. LMW-OPS induced significant increases in ERIC and p38 MAPK phosphorylation, but not c-Jun N-terminal kinase (JNK) phosphorylation, in BMDCs. Our results indicate that, in part, LMW-OPS can induce maturation of BMDCs in a MyD88-dependent and Toll-like receptor (TLR) 4-independent manner. LMW-OPS may enhance acquired immunity by modulating the function of dendritic cells. (C) 2017 Elsevier B.V. All rights reserved.
资助项目	Shandong Provincial Natural Science Foundation, China[ZR2014HM038]
WOS关键词	TOLL-LIKE RECEPTORS ; CANCER VACCINES ; IN-VITRO ; T-CELLS ; MATURATION ; INDUCTION ; IMMUNITY ; RECOGNITION ; GENERATION
WOS研究方向	Immunology ; Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000394918700021
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272754]
专题	上海中药现代化研究中心
通讯作者	Zhong, Ming
作者单位	1.Jining Med Coll, Inst Tumor Pharmacol, Xueyuan Rd 669, Rizhao 276826, Peoples R China; 2.S&V Biol Sci & Technol Co Ltd, Heying Rd 8, Beijing 102200, Peoples R China 3.Shandong Anal & Test Ctr, Keyuan Rd 19, Jinan 250014, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Haike Rd 501, Shanghai, Peoples R China; 5.Peoples Hosp Rizhao, Taian Rd 126, Rizhao 276826, Peoples R China; 6.Osaka Univ, Grad Sch Med, Div Gene Therapy Sci, Yamadaoka2-2, Suita, Osaka 5650871, Japan;
推荐引用方式 GB/T 7714	Zhong, Ming,Zhong, Cheng,Wang, Tingting,et al. Activation of dendritic cells by low molecular weight oyster polysaccharides[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2017,44:183-190.
APA	Zhong, Ming.,Zhong, Cheng.,Wang, Tingting.,Hu, Pei.,Wang, Guanghui.,...&Che, Jiantu.(2017).Activation of dendritic cells by low molecular weight oyster polysaccharides.INTERNATIONAL IMMUNOPHARMACOLOGY,44,183-190.
MLA	Zhong, Ming,et al."Activation of dendritic cells by low molecular weight oyster polysaccharides".INTERNATIONAL IMMUNOPHARMACOLOGY 44(2017):183-190.