Development and application of bio-sample quantification to evaluate stability and pharmacokinetics of inulin-type fructo-oligosaccharides from Morinda Officinalis

doi:10.1016/j.jpba.2018.04.028

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Development and application of bio-sample quantification to evaluate stability and pharmacokinetics of inulin-type fructo-oligosaccharides from Morinda Officinalis
	Chi, Liandi 1; Chen, Lingxiao 1; Zhang, Jiwen2 ; Zhao, Jing1 ; Li, Shaoping 1; Zheng, Ying 1
刊名	JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
	2018-07-15
卷号	156 页码:125-132
关键词	lnulin-type fructooligosaccharides (FOS) Morindo Officinalis Stability Absorption Bioavailability Gut microbiota
ISSN号	0731-7085
DOI	10.1016/j.jpba.2018.04.028
文献子类	Article
英文摘要	Inulin-type fructooligosaccharides (FOS) purified from Morinda Officinalis, with degrees of polymerization (DP) from 3 to 9, have been approved in China as an oral prescribed drug for mild and moderate depression episode, while the stability and oral absorption of this FOS mixtures are largely unknown. As the main active component and quality control marker for above FOS, DP5 was selected as the representative FOS in this study. Desalting method by ion exchange resin was developed to treat bio-sample, followed by separation and quantification by high performance liquid chromatography-charged aerosol detector. Results showed that the DP5 was stepwisely hydrolyzed in simulated gastric fluid and gut microbiota, while maintained stable in intestinal fluid. DP5 has poor permeability across Caco-2 monolayer with P-app of 5.22 x 10(-7) cm/s, and very poor oral absorption with bioavailability of (0.50 +/- 0.12)% in rat. In conclusion, FOS in Morinda Officinalis demonstrated poor chemical stability in simulated gastric fluid and human gut microbiota, and low oral absorption in rats. (C) 2018 Elsevier B.V. All rights reserved.
资助项目	Research Committee of University of Macau[MYRG2016-00090-ICMS-QRCM]
WOS关键词	PERFORMANCE LIQUID-CHROMATOGRAPHY ; PLANTS ; MODEL
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000435228400014
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279658]
专题	药物制剂研究中心
通讯作者	Zheng, Ying
作者单位	1.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Chi, Liandi,Chen, Lingxiao,Zhang, Jiwen,et al. Development and application of bio-sample quantification to evaluate stability and pharmacokinetics of inulin-type fructo-oligosaccharides from Morinda Officinalis[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2018,156:125-132.
APA	Chi, Liandi,Chen, Lingxiao,Zhang, Jiwen,Zhao, Jing,Li, Shaoping,&Zheng, Ying.(2018).Development and application of bio-sample quantification to evaluate stability and pharmacokinetics of inulin-type fructo-oligosaccharides from Morinda Officinalis.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,156,125-132.
MLA	Chi, Liandi,et al."Development and application of bio-sample quantification to evaluate stability and pharmacokinetics of inulin-type fructo-oligosaccharides from Morinda Officinalis".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 156(2018):125-132.