A novel tumor-targeting treatment strategy uses energy restriction via co-delivery of albendazole and nanosilver

doi:10.1007/s12274-018-2032-x

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	A novel tumor-targeting treatment strategy uses energy restriction via co-delivery of albendazole and nanosilver
	Liang, Jianming 1,3,6; Li, Ruixiang 1,6; He, Yuwei 1,6; Ling, Chengli 2; Wang, Qi 4; Huang, Yongzhuo5 ; Qin, Jing 1,6; Lu, Weigen 3; Wang, Jianxin 1,6
刊名	NANO RESEARCH
	2018-09
卷号	11 期号:9 页码:4507-4523
关键词	albendazole nano silver co-delivery tumor targeting energy metabolism
ISSN号	1998-0124
DOI	10.1007/s12274-018-2032-x
文献子类	Article
英文摘要	Although nanotechnology has been rapidly developed and applied in tumor targeting, the outcome of chemotherapy remains greatly restricted by the toxicity of cytotoxic drugs in normal tissues and cells. Therefore, the development of alternative delivery systems, with few side effects in normal cells, has attracted increasing attention. Energy restriction is a novel and promising approach to cancer treatment, which can restrict tumor growth via inhibition of cellular energy metabolism. In this study, a novel tumor targeting system, based on folate-conjugated bovine serum albumin (BSA), was developed to co-deliver albendazole and nanosilver simultaneously, to restrain the energy metabolism of tumor cells. This nanosystem showed stronger anti-tumor efficacy than those using nanoparticles without folic acid modification, nanosilver, or albendazole, both in vitro and in vivo. This nanosystem depleted cellular ATP via direct inhibition of glycolytic enzymes and mitochondrial damage, resulting in inhibition of proliferation, cell-cycle arrest, and apoptosis of tumor cells. The enhanced anti-tumor activity contributed to the tumor-targeting ability of this system, resulting in specific energy inhibition in tumor cells. Toxicity evaluation was performed to confirm the safety of this system. This nanosystem provides an efficient and safe strategy for tumor therapy.
资助项目	National Natural Science Foundation of China[81690263] ; National Natural Science Foundation of China[81361140344] ; National Basic Research Program of China[2013CB932500] ; Development Project of Shanghai Peak Disciplines - Integrated Medicine[20150407]
WOS关键词	BOVINE SERUM-ALBUMIN ; SILVER NANOPARTICLES ; DRUG-DELIVERY ; CANCER-CELLS ; IN-VITRO ; ELECTRON-TRANSFER ; OXIDATIVE STRESS ; PYRUVATE-KINASE ; OVARIAN-CANCER ; FOLIC-ACID
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
CSCD记录号	CSCD:6315750
出版者	TSINGHUA UNIV PRESS
WOS记录号	WOS:000441237100005
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279605]
专题	药物制剂研究中心
通讯作者	Lu, Weigen; Wang, Jianxin
作者单位	1.Minist Educ, Key Lab Smart Drug Delivery, Shanghai 201203, Peoples R China; 2.Chengdu Univ Tradit Chinese Med, Sch Pharm, 1166 Liu Tai Ave, Chengdu 610072, Sichuan, Peoples R China 3.China State Inst Pharmaceut Ind, Shanghai Inst Pharmaceut Ind, 285 Gebaini Rd, Shanghai 201203, Peoples R China; 4.Guangzhou Univ Tradit Chinese Med, Inst Clin Pharmacol, Guangzhou 510006, Guangdong, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China; 6.Fudan Univ, Sch Pharm, Dept Pharmaceut, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Liang, Jianming,Li, Ruixiang,He, Yuwei,et al. A novel tumor-targeting treatment strategy uses energy restriction via co-delivery of albendazole and nanosilver[J]. NANO RESEARCH,2018,11(9):4507-4523.
APA	Liang, Jianming.,Li, Ruixiang.,He, Yuwei.,Ling, Chengli.,Wang, Qi.,...&Wang, Jianxin.(2018).A novel tumor-targeting treatment strategy uses energy restriction via co-delivery of albendazole and nanosilver.NANO RESEARCH,11(9),4507-4523.
MLA	Liang, Jianming,et al."A novel tumor-targeting treatment strategy uses energy restriction via co-delivery of albendazole and nanosilver".NANO RESEARCH 11.9(2018):4507-4523.